Rabbit Anti-CPT2 Polyclonal Antibody#abs136609
Please note that the price provided is for reference purposes only. For more information on the detailed pricing, please reach out to our seller, Vecent. It is important to ensure that you seek clarification from our seller on all pricing details before making any purchases. Western blot...
Description
| Catalog-specification | Delivery time | USD price |
abs136609-100ug | 1-2 Weeks | 301.0 |
abs136609-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for reference purposes only. For more information on the detailed pricing, please reach out to our seller, Vecent. It is important to ensure that you seek clarification from our seller on all pricing details before making any purchases.
| Overview | |
catalog | abs136609 |
Description | The gene in question encodes a nuclear protein that is responsible for transporting itself into the inner membrane of mitochondria. Alongside carnitine palmitoyltransferase I, this protein works to oxidize long-chain fatty acids found within the structure of mitochondria. When there are problems associated with this gene, mitochondrial long-chain fatty-acid (LCFA) oxidation disorders can occur. |
| Other names | Carnitine palmitoyltransferase II, also known as CPT2, plays a crucial role in mitochondrial metabolism. This enzyme is responsible for the transportation of long-chain fatty acids into the mitochondria for beta-oxidation and energy production. CPT2 deficiency is a rare genetic disorder that affects this enzyme's function and leads to impaired fatty acid metabolism. CPT2, also referred to as carnitine O-palmitoyltransferase 2, is primarily located in the mitochondria and is involved in the transfer of acyl groups from carnitine to CoA, facilitating the entry of fatty acids into the mitochondrial matrix. This process is essential for the breakdown of fatty acids to generate ATP, the cell's main energy source. The human CPT2 gene encodes the CPT2 protein, which contains a unique set of amino acids responsible for its catalytic activity. Mutations in this gene can result in CPT2 deficiency, which may present with symptoms such as muscle weakness, hypoketotic hypoglycemia, and cardiomyopathy. CPT2 deficiency is typically diagnosed through genetic testing and biochemical analysis. Treatment options for this disorder involve dietary modifications, including a low-fat, high-carbohydrate diet, and the supplementation of certain substances to enhance fatty acid oxidation. In conclusion, CPT2, also known as carnitine palmitoyltransferase II, is a vital enzyme involved in fatty acid metabolism within the mitochondria. Deficiencies in this enzyme can lead to significant metabolic disturbances and require appropriate management strategies. |
| Source | Rabbit |
| Specificity | The antibody for CPT2 can effectively detect the complete levels of endogenous CPT2. This means that the antibody can be used for various applications where quantification of CPT2 is required. It is an essential tool for researchers working on fatty acid oxidation and metabolism. The antibody's ability to detect endogenous CPT2 accurately makes it a valuable tool for studying the functional significance of CPT2 in various cell types and conditions. With this information, researchers can better understand the mechanism and role of CPT2 in metabolism and disease progression. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Bovine;Horse; |
| Antigen | CPT2 |
| Application | For Western blot, dilutions of 1:500 up to 1:2000 are recommended. Immunohistochemistry requires a dilution range of 1:50 to 1:100, whereas for IF/ICC applications, dilutions of 1:100 to 1:500 are recommended. When using ELISA with a peptide substrate, we suggest dilutions of 1:20000 to 1:40000 for optimal results. It is important to note that proper dilution optimization may be necessary for each individual experiment, depending on the specific protocol and sample type. |
| Immunogen | A synthetic peptide of human CPT2. |
| MW | 74kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Peptide affinity chromatography with SulfoLink™ Coupling Resin was employed to purify the antiserum. Reorganizing the original information, we successfully utilized the SulfoLink™ Coupling Resin for the purification process. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine. |
| Celluar localization | Mitochondrion;Nucleus; |
| UniPort | P23786 |
Western blot analysis of extracts ofMouse fetal kidney tissue lysate, using CPT2 antibody. |Immunohistochemistry of paraffin-embeddedhuman esophagus cancer tissue using CPT2antibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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