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Rabbit Anti-CLTR2 Polyclonal Antibody#abs135219

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Description

Catalog-specification	Delivery time	USD price
abs135219-100ug	1-2 Weeks	301.0
abs135219-50ug	1-2 Weeks	201.0

Overview
catalog	abs135219
Other names	The CYSLT2 receptor, also known as CysLTR2 or Cysteinyl leukotriene CysLT2 receptor, is a G protein coupled receptor that plays a crucial role in mediating the biological effects of cysteinyl leukotrienes. It is encoded by the CLTR2_HUMAN gene and is expressed primarily in the respiratory tract, as well as in other tissues such as the heart, liver, and spleen. Activation of the CYSLT2 receptor by cysteinyl leukotrienes leads to the activation of downstream signaling pathways that contribute to the pathogenesis of various inflammatory diseases such as asthma, rhinitis, and dermatitis. As such, the CYSLT2 receptor has been identified as a potential target for the development of novel anti-inflammatory therapies. In addition to its role in inflammation, the CYSLT2 receptor has also been implicated in the regulation of vascular tone and blood pressure. Its expression in the heart suggests a potential role in the regulation of cardiac function as well. The receptor is also known by other names such as CYSLT2R, Cysteinyl leukotriene receptor 2, G protein coupled receptor, GPCR21, GPCR HG57, hGPCR21, HPN321, and PSEC0146. In conclusion, the CYSLT2 receptor is an important mediator of the biological effects of cysteinyl leukotrienes and is involved in various physiological and pathological processes. Its identification as a potential therapeutic target holds promise for the development of novel anti-inflammatory therapies and treatments for cardiovascular and other diseases.
Source	Rabbit
Specificity	The endogenous levels of total CLTR2 are detected by the CLTR2 Antibody. A highly similar content can be generated by rearranging the original information as follows: The CLTR2 Antibody is capable of detecting the total CLTR2 levels that naturally occur within the system.
Species Reactivity	Human
Antigen	CLTR2
Application	We recommend WB with a dilution range of 1:500 to 1:1000 for better results. For IF/ICC, a dilution of 1:100 to 1:500 is suggested. ELISA using peptide antigens can be performed with a dilution range of 1:20000 to 1:40000. Following these dilution guidelines will ensure accurate and reliable experimental outcomes.
Immunogen	A synthesized peptide.
MW	35 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification via peptide affinity chromatography. To ensure the highest level of purity, this process was carefully carried out to yield a highly refined product.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the product is stored at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	-20°CIgG，pH7.4，150mM NaCl，0.02％50％。，12。
Target
Background	Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.
Tissue specificity	Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.
Celluar localization	Plasma Membrane;
UniPort	Q9NS75