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Rabbit Anti-CDO1 Polyclonal Antibody#abs139694

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Description

Catalog-specification	Delivery time	USD price
abs139694-100ug	1-2 Weeks	301.0
abs139694-50ug	1-2 Weeks	201.0

Overview
catalog	abs139694
Other names	Cysteine dioxygenase type 1, also known as CDO 1 or CDO-I, is a cytosolic enzyme that plays an important role in the metabolism of cysteine. CDO-I is responsible for the oxidation of cysteine to cysteine sulfinic acid, which is a key step in the degradation of cysteine and the production of taurine. CDO 1, also referred to as CDO1_HUMAN, is a protein that is encoded by the CDO gene in humans. It is involved in the regulation of cysteine levels in the body and is crucial for maintaining proper cysteine homeostasis. CDO 1 performs its enzymatic function by utilizing molecular oxygen and iron as cofactors. The activity of CDO-I is crucial for various physiological processes, such as the synthesis of taurine, a neurotransmitter and osmoregulator, as well as the detoxification of harmful sulfur compounds. Deficiencies in CDO 1 activity have been associated with various pathological conditions, including hypercysteinemia, neurological disorders, and eye diseases. Understanding the function and regulation of CDO 1 is important for unraveling the complex mechanisms governing cysteine metabolism and its implications in human health. Ongoing research aims to elucidate the precise role of CDO-I and explore its potential as a therapeutic target for disorders related to cysteine metabolism.
Source	Rabbit
Specificity	The CDO1 Antibody is capable of identifying the overall levels of endogenous CDO1 present in an organism. The generated content is similar to the original text content by rearranging the statements and avoiding direct copying.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;Horse
Antigen	CDO1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CDO1.
MW	23 kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the quality and effectiveness of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to numerous freeze/thaw cycles as this can compromise its integrity and potency. By following these guidelines, you can prolong the shelf-life of the product and maintain its efficacy for maximal benefit.
Storage buffer	The storage condition for Rabbit IgG is at -20 °C in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It remains stable for a duration of 12 months starting from the date of receipt.
Target
Background	Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
Tissue specificity	Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells.
Posttranslational modification	The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.
Celluar localization	Cytosol;
UniPort	Q16878