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Rabbit Anti-CD151 Polyclonal Antibody#abs136219

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Description

Catalog-specification	Delivery time	USD price
abs136219-100ug	1-2 Weeks	301.0
abs136219-50ug	1-2 Weeks	201.0

Overview
catalog	abs136219
Description	This particular gene encodes a protein that belongs to the tetraspanin family, also referred to as the transmembrane 4 superfamily. Like most members of this family, the protein is found on the cell surface and contains four hydrophobic domains. These proteins are involved in signaling processes that regulate cell development, activation, growth, and motility. Specifically, this glycoprotein interacts with integrins and other proteins from the transmembrane 4 superfamily, forming complexes. It plays a role in cell adhesion and may influence the trafficking and/or function of integrins. Notably, this protein facilitates cell motility, invasion, and the spread of cancer cells. Various alternative forms of the gene, resulting from alternative splicing, have been identified, but they encode the same protein.
Other names	CD151, also known as CD151 antigen and hemidesmosomal tetraspanin CD151, is a transmembrane protein that plays a role in cell adhesion and migration. It is encoded by the CD151 gene and is also known as the Raph blood group antigen. CD151 has various alternative names, including MER2, PETA-3, Platelet endothelial tetraspan antigen 3, platelet surface glycoprotein gp27, and Tetraspanin-24, among others. CD151 is a member of the tetraspanin family, which is characterized by four transmembrane domains and conserved cysteine residues. It forms a complex with integrins and other transmembrane proteins, such as laminin and collagen, to regulate cell adhesion and migration. CD151 is expressed in various cell types, including platelets, endothelial cells, and epithelial cells. CD151 is involved in several biological processes, such as cell proliferation, differentiation, and survival. It also plays a role in the formation and maintenance of hemidesmosomes, which are structures that anchor cells to the extracellular matrix. Dysregulation of CD151 expression has been implicated in various diseases, including cancer, thrombosis, and kidney disease. In summary, CD151 is a transmembrane protein that plays a critical role in cell adhesion and migration. It is expressed in various cell types and regulates several biological processes. Dysregulation of CD151 expression has been linked to several diseases, highlighting its importance in maintaining cellular homeostasis.
Source	Rabbit
Specificity	The CD151 Antibody is capable of recognizing the complete amount of CD151 that naturally occurs within a sample. To create novel content that accurately reflects this information, one could reword this statement by saying that the antibody for CD151 is effective in detecting the total endogenous levels of this protein in a given sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Horse
Antigen	CD151
Application	The recommended dilution ratios for the protein WB analysis is between 1:500 to 1:2000, for IHC it is 1:50 to 1:200, and for IF/ICC it is 1:100 to 1:500. Additionally, for ELISA using a peptide substrate, the appropriate dilution ratio is 1:20000 to 1:40000. It is important to follow these recommended ratios to ensure optimal results in your experiments.
Immunogen	A synthesized peptide derived from human CD151.
MW	28kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Essential for the proper assembly of the glomerular and tubular basement membranes in kidney.
Tissue specificity	Expressed in a variety of tissues including vascular endothelium and epidermis. Expressed on erythroid cells, with a higher level of expression in erythroid precursors than on mature erythrocytes.
Celluar localization	Cytosol;Extracellular region or secreted;Plasma Membrane;
UniPort	P48509