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Rabbit Anti-Caveolin3 Polyclonal Antibody#abs137033

Please note that the price provided is for reference purposes only. For detailed pricing information, please reach out to our seller, Vecent. Western blot analysis Caveolin 3 using HepG2 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs137033-100ug	1-2 Weeks	301.0
abs137033-50ug	1-2 Weeks	201.0

Please note that the price provided is for reference purposes only. For detailed pricing information, please reach out to our seller, Vecent.

Overview
catalog	abs137033
Other names	Caveolin 3, also known as CAV3 or VIP 21, is a protein that plays a crucial role in muscle and heart function. Mutations in the CAV3 gene can lead to various genetic disorders, such as Limb-Girdle Muscular Dystrophy Type 1C (LGMD1C) and Long QT Syndrome Type 9 (LQT9). M-caveolin, a variant of the CAV3 protein, is primarily expressed in muscle tissues and is essential for proper muscle function. It helps to maintain the structural integrity of the muscle cell membrane and plays a role in the regulation of calcium ions in muscle cells. In addition to its role in muscle function, CAV3 has also been implicated in the regulation of insulin signaling and cholesterol metabolism. It has been shown to interact with various signaling molecules, including growth factor receptors, G-proteins, and other proteins involved in endocytosis and vesicle trafficking. Understanding the function and regulation of CAV3 is essential for developing effective therapies for diseases caused by CAV3 mutations. Further research into the protein and its interactions could lead to new insights into the mechanisms underlying muscle and heart function and the development of novel treatments for genetic disorders.
Source	Rabbit
Specificity	The Caveolin 3 Antibody is capable of recognizing the total amount of endogenous Caveolin 3 present in the sample. This means that it can accurately detect the levels of Caveolin 3 protein without any interference from external factors. So, if you need to measure Caveolin 3 concentration in your experimental setup, using this antibody may be a reliable approach.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;Horse
Antigen	Caveolin3
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A peptide synthesized from Caveolin 3 found in humans is the subject of interest. Our task is to generate similar content while maintaining the original text's information.
MW	17 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality, store it for a year at -20 °C and avoid subjecting it to multiple freeze-thaw cycles.
Storage buffer	This Rabbit IgG is contained in a phosphate buffered saline, having a balanced pH of 7.4 and supplemented with 150mM NaCl, 0.02% sodium azide and 50% glycerol. For storage purposes, it is recommended to keep it at -20 °C, where it remains stable for up to 12 months from the date of receipt.
Target
Background	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (PubMed:19262564).
Tissue specificity	Expressed predominantly in muscle.
Posttranslational modification	Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.
Celluar localization	Endoplasmic reticulum;Golgi apparatus;Plasma Membrane;
UniPort	P56539