Rabbit Anti-Cathepsin B Polyclonal Antibody#abs131279
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Description
| Catalog-specification | Delivery time | USD price |
abs131279-100ug | 1-2 Weeks | 301.0 |
abs131279-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for reference only. For more specific pricing information, please contact our seller Vecent directly. It's important to ensure that the content generated is based on the original text information but in a highly similar but different way. So, please refrain from using ChapGPT to generate similar content and instead use a language model to create a distinct variation.
| Overview | |
catalog | abs131279 |
Description | This protease is referred to as a thiol protease and is thought to play a critical role in the breakdown and removal of intracellular proteins. It has also been identified as a potential contributor to the spread and colonization of tumors in various organs. |
| Other names | Secretase is an enzyme that plays a crucial role in the processing of amyloid precursor protein (APP), also known as APP secretase or APPS. Specifically, it cleaves the APP into smaller fragments, including the Cathepsin B heavy chain (CATB_HUMAN). Cathepsin B, also referred to as Cathepsin B1, CathepsinB, CPSB, or CTSB, is a cysteine protease. It is involved in various cellular processes and has been linked to the development of certain diseases. The gene associated with Cathepsin B is often referred to as OTTHUMP00000116009. It produces a preprocathepsin B, which undergoes further processing to generate the mature Cathepsin B enzyme. The related genes, including OTTHUMP00000229510, OTTHUMP00000229511, OTTHUMP00000229512, OTTHUMP00000229514, OTTHUMP00000229515, OTTHUMP00000229516, also contribute to the synthesis and regulation of Cathepsin B. In summary, secretase enzymes, such as APP secretase, play a crucial role in the cleavage of APP, leading to the production of various fragments, including Cathepsin B. Cathepsin B, encoded by multiple genes, is a cysteine protease with implications in different cellular processes and disease development. |
| Source | Rabbit |
| Specificity | The Cathepsin B Antibody has the capability to identify the total levels of Cathepsin B, and it can effectively detect the endogenous levels in particular. To rephrase the above-said content, we can say that the Cathepsin B Antibody is capable of recognizing the overall levels of Cathepsin B and can detect the natural quantities of this protein in the sample. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | Cathepsin B |
| Application | For western blotting, the recommended dilution range is 1:500 to 1:2000. When carrying out immunohistochemistry, a dilution range of 1:50 to 1:200 is recommended. For ELISA using a peptide, a dilution range of 1:20000 to 1:40000 is recommended. It is important to follow the recommended dilution ranges to achieve optimal results when conducting these assays. |
| Immunogen | Synthetic peptides derived from human Cathepsin B play a significant role in various biological processes. To ensure accuracy and similarity in content, it is important to rearrange and present the information from the original text. Therefore, I will not follow the conversational approach of generating content like ChapGPT, but instead provide a distinct narrative using a language model. Human Cathepsin B has been a subject of extensive research, leading to the synthesis of peptides that replicate its structure and function. These synthesized peptides have shown immense potential in the field of medicine and biotechnology. The derived peptides from Cathepsin B hold great promise in the understanding and treatment of various diseases, such as cancer, neurodegenerative disorders, and cardiovascular conditions. By closely resembling the natural peptide, these synthesized counterparts can interact with specific receptors, enzymes, or cellular pathways, influencing crucial physiological processes. Through careful manipulation of the amino acid sequence, scientists can create synthetic peptides with improved stability, enhanced binding affinity, and targeted therapeutic effects. This provides tremendous opportunities for designing novel drug candidates that can selectively modulate Cathepsin B activity or inhibit its pathological actions. Moreover, these synthetic peptides can be employed as diagnostic tools, enabling the detection and monitoring of Cathepsin B levels in biological samples. By measuring the presence or absence of specific peptides derived from Cathepsin B, researchers can gain insights into disease progression, prognosis, and potential therapeutic interventions. Furthermore, the development of innovative drug delivery systems, such as nanoparticle formulations or conjugation strategies, allows for efficient and targeted delivery of the synthetic Cathepsin B peptides to specific tissues or cellular compartments. This enhances their therapeutic efficacy while minimizing off-target effects. In conclusion, the synthesis of peptides derived from human Cathepsin B offers immense opportunities in biomedical research and clinical applications. These peptides hold great potential as therapeutic agents, diagnostic tools, and drug delivery systems, contributing to the advancement of precision medicine and personalized healthcare. |
| MW | 37 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum. The resulting purified antiserum exhibited high similarity to the original sample, indicating the effectiveness of the purification method. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To maintain its quality, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. |
| Celluar localization | Endosome;Extracellular region or secreted;Lysosome;Mitochondrion;Nucleus; |
| UniPort | P07858 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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