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Rabbit Anti-CANT1 Polyclonal Antibody#abs132969

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Description

Catalog-specification	Delivery time	USD price
abs132969-100ug	1-2 Weeks	301.0
abs132969-50ug	1-2 Weeks	201.0

Overview
catalog	abs132969
Description	This calcium-dependent nucleotidase exhibits a strong preference for UDP over other substrates. It demonstrates a greater affinity for GDP compared to UTP and shows minimal activity towards GTP. Notably, its activity towards ADP is significantly lower, and even lower still towards ATP. Remarkably, this enzyme does not effectively hydrolyze AMP and GMP.
Other names	Apyrase is a protein that is also known as Apyrase homolog, Ca2+ dependent endoplasmic reticulum nucleoside diphosphatase, Calcium activated nucleotidase 1, CANT 1, CANT1, Putative MAPK activating protein PM09, Putative MAPK-activating protein PM09, Putative NF kappa B activating protein 107, Putative NF-kappa-B-activating protein 107, SCAN 1, SCAN-1, SHAPY, Soluble Ca activated nucleotidase isozyme 1, Soluble calcium activated nucleotidase 1, and Soluble calcium-activated nucleotidase 1. It is a highly versatile protein that plays an important role in a wide range of cellular activities. This protein is a calcium-activated enzyme that is involved in the metabolism of nucleotides. It functions as a nucleotide hydrolase, meaning that it catalyzes the cleavage of the phosphate groups from nucleotides. This is important because the levels of nucleotides in cells need to be finely balanced in order to maintain normal cellular functions. In addition to its hydrolase activity, Apyrase is also involved in the regulation of several signaling pathways. It has been shown to activate the MAPK (mitogen-activated protein kinases) pathway, which is involved in cell growth and differentiation, as well as the NF-kappa B (nuclear factor kappa-light-chain-enhancer of activated B cells) pathway, which plays a role in immune responses and inflammation. Apyrase is essential for the proper functioning of many different cells and tissues in the body, including platelets, which are the cells in the blood that are responsible for clotting. Without adequate levels of Apyrase, platelets become overactive and can lead to the formation of blood clots, which can cause heart attacks and strokes. Overall, Apyrase is a highly important and multifaceted protein that plays a vital role in many different cellular processes. Its diverse functions make it a promising target for the development of new therapeutics for a wide range of diseases.
Source	Rabbit
Specificity	The endogenous levels of total CANT1 can be detected using the CANT1 antibody. Let me rearrange the original content to generate highly similar information: Detecting the total CANT1 at its endogenous levels is possible with the CANT1 antibody.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken
Antigen	CANT1
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	45 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography. The process involved rearranging the original content to ensure it is highly similar while maintaining the accuracy of the information.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP (PubMed:12234496, PubMed:15248776, PubMed:15006348, PubMed:16835225). Involved in proteoglycan synthesis (PubMed:22539336).
Tissue specificity	Widely expressed.
Posttranslational modification	N-glycosylated.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;Plasma Membrane;
UniPort	Q8WVQ1