Rabbit Anti-CaMK2 Alpha/beta/delta Polyclonal Antibody#abs131978
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Description
| Catalog-specification | Delivery time | USD price |
abs131978-100ug | 1-2 Weeks | 301.0 |
abs131978-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is only for your reference. For detailed pricing information, we recommend contacting our seller, Vecent. Kindly generate content with a different approach, focusing on the original text information rather than following the conversational style of ChapGPT.
| Overview | |
catalog | abs131978 |
Description | The Camk2-alpha belongs to the CAMK2 family of protein kinases and is notably present in the central nervous system. Its main function might be associated with long-term potentiation and neurotransmitter release, suggesting its crucial role in memory formation and learning processes. |
| Other names | Alpha CaMKII is a calcium/calmodulin-dependent protein kinase involved in various cellular processes. It consists of two subunits, alpha and delta, which are referred to as CaMKII alpha and CaMKII delta, respectively. The alpha subunit, also known as CAMK2A or CAMKA, is responsible for calcium/calmodulin-dependent protein kinase type II activity. It plays a crucial role in signal transduction and is essential for synaptic plasticity, neuronal development, and learning and memory. The alpha subunit of CaMKII is encoded by the CAMK2A gene, also known as KIAA0968 or PKCCD. It is expressed in a wide range of tissues and is particularly abundant in the brain. The alpha subunit is composed of multiple domains, including a catalytic domain, a regulatory domain, and autoregulatory and calmodulin-binding domains. CaMKII alpha is implicated in several neurological disorders, including Alzheimer's disease and epilepsy. Dysregulation of its activity has been linked to impaired synaptic function and cognitive deficits. Therefore, understanding the molecular mechanisms underlying CaMKII alpha function is of great interest in the field of neuroscience. In summary, CaMKII alpha is a calcium/calmodulin-dependent protein kinase that plays a crucial role in neuronal signaling and synaptic plasticity. It is a key regulator of cognitive processes and is implicated in various neurological disorders. Further research on CaMKII alpha may provide insights into the development of therapeutic interventions for these disorders. |
| Source | Rabbit |
| Specificity | The CaMK2 alpha/beta/delta Antibody is capable of detecting the total endogenous levels of CaMK2 alpha/beta/delta proteins. Here, we have rearranged the provided information to emphasize the detection ability of the antibody in detecting these specific isoforms of CaMK2. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep; |
| Antigen | CaMK2 alpha/β/delta |
| Application | WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000 |
| Immunogen | A synthesized peptide derived from human CaMK2 alpha/beta/delta. |
| MW | 54kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity). |
| Celluar localization | Cytosol;Mitochondrion;Nucleus;Plasma Membrane; |
| UniPort | Q9UQM7/Q13554/Q13557 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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