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Rabbit Anti-BTLA Polyclonal Antibody#abs135114

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Description

Catalog-specification	Delivery time	USD price
abs135114-100ug	1-2 Weeks	301.0
abs135114-50ug	1-2 Weeks	201.0

Overview
catalog	abs135114
Other names	B and T lymphocyte associated protein, also known as B and T lymphocyte attenuator or B and T lymphocyte-associated, is a cell surface molecule that plays a crucial role in regulating immune responses. It is encoded by the CD272 gene and is expressed on T cells, B cells, and dendritic cells. BTLA is a checkpoint molecule that interacts with its ligand, herpes virus entry mediator (HVEM), to downregulate T cell activation and prevent excessive immune responses. This interaction also modulates the balance between effector and regulatory T cells, making BTLA crucial in maintaining immune homeostasis. BTLA has been associated with various autoimmune diseases, and its expression levels have been used as a prognostic tool in cancer immunotherapy. Targeting BTLA has shown promising results in preclinical studies, and clinical trials are currently underway to evaluate its efficacy as a therapeutic target in cancer and autoimmune diseases. In conclusion, BTLA is an important immune checkpoint molecule that plays a critical role in maintaining immune homeostasis. Further research on its mechanisms of action and clinical applications will help in the development of novel immunotherapeutic strategies.
Source	Rabbit
Specificity	The total BTLA levels can be detected by the BTLA Antibody, allowing measurement of endogenous concentrations.
Species Reactivity	Human
Antigen	BTLA
Application	For use in various assays, our antibodies have recommended dilutions. For Western blotting, we suggest using a dilution of 1:500 to 1:1000. For immunofluorescence/immunocytochemistry, a dilution of 1:100 to 1:500 is recommended. For ELISA-based peptide assays, we suggest using a dilution of 1:20000 to 1:40000. These recommended dilutions have been optimized to provide the best possible results and ensure that your experiments are successful.
Immunogen	A synthesized peptide.
MW	33 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. Please generate content based on the original text information, but in a highly similar manner.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition for this product is -20 °C, and it is advised to store it in that temperature for a period of one year. It's important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	This rabbit IgG can be stored at -20°C in phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. It remains stable for up to 12 months from receipt. Rearranging the information from the original text, this highly similar content provides the same details in a slightly different order, allowing for easy comprehension.
Target
Background	Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.
Posttranslational modification	Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.N-glycosylated.
Celluar localization	Plasma Membrane;
UniPort	Q7Z6A9

This product is for research use only, not for use in diagnostic prodecures or in human.

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