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Rabbit Anti-BSG Polyclonal Antibody#abs135982

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Description

Catalog-specification	Delivery time	USD price
abs135982-100ug	1-2 Weeks	301.0
abs135982-50ug	1-2 Weeks	201.0

Overview
catalog	abs135982
Description	Basigin (EMMPRIN, CD147) is a receptor protein that belongs to the immunoglobulin superfamily and is classified as a type I integral membrane protein (1). It is known to have four different isoforms, with isoform 2 being the most prevalent (2). The protein undergoes glycosylation and has been linked to various functions. One of its prominent roles is in promoting the secretion of matrix metalloproteinases by neighboring fibroblasts, which is believed to contribute to tumor progression (2-4). Numerous studies have observed high expression levels of Basigin in tumor cells, suggesting a potential correlation with the malignancy of tumors (5,6). Recent research has identified the BASIGIN gene as a target regulated by Slug, indicating Basigin's involvement in the process of epithelial-mesenchymal transition (7). Additionally, Basigin has been identified as a marker for a specific subset of highly suppressive regulatory T cells (8) and serves as an essential receptor for the malarial parasite Plasmodium falciparum on human red blood cells (9). By rearranging the provided information, the key details of Basigin's structure, functions, and associations with different biological processes are maintained.
Other names	Basigin, also known as CD147 or Ok blood group antigen, is an important protein involved in various biological processes. It is encoded by the BASI_HUMAN gene and is widely expressed in different tissues and cell types. Basigin plays a crucial role in the blood-brain barrier as the HT7 antigen and is known to interact with other proteins and extracellular matrix components. This protein is also referred to as collagenase stimulatory factor and extracellular matrix metalloproteinase inducer (EMMPRIN). It has been identified as a leukocyte activation antigen M6 and is commonly known as M6. Additionally, it goes by the names neurothelin, TCSF, and tumor cell-derived collagenase stimulatory factor. The OK blood group is associated with basigin, and CD147 is a commonly used name for the protein. Understanding the functions and interactions of basigin can provide insights into its involvement in various biological mechanisms.
Source	Rabbit
Specificity	Total BSG can be detected using the BSG Antibody, which specifically targets endogenous levels of the protein. This means that the antibody is capable of identifying all forms of BSG in a sample, providing accurate and reliable results. By detecting total BSG levels, the antibody can help researchers gain insights into the function and regulation of this important protein.
Species Reactivity	Human
Antigen	BSG
Application	The recommended dilution for Western blot (WB) ranges from 1:500 to 1:2000, while for Immunohistochemistry (IHC) it is between 1:50 and 1:200. For Immunofluorescence/Immunocytochemistry (IF/ICC), the suggested dilution is 1:100 to 1:500. When it comes to ELISA with peptide antigens, the recommended dilution is 1:20000 to 1:40000. It is important to note that these dilutions ensure optimal results and should be followed for accurate and reliable data.
Immunogen	A synthesized peptide derived from human BSG.
MW	42kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
Tissue specificity	Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
Posttranslational modification	N-glycosylated.
Celluar localization	Extracellular region or secreted;Golgi apparatus;Mitochondrion;Plasma Membrane;
UniPort	P35613