Rabbit Anti-BRE Polyclonal Antibody#abs134988
Please be advised that the price provided is only a reference and for detailed pricing information, please get in touch with our seller Vecent. It is important to note that the final cost may differ from the initial estimate and our seller can provide you with all the necessary information....
Description
| Catalog-specification | Delivery time | USD price |
abs134988-100ug | 1-2 Weeks | 301.0 |
abs134988-50ug | 1-2 Weeks | 201.0 |
Please be advised that the price provided is only a reference and for detailed pricing information, please get in touch with our seller Vecent. It is important to note that the final cost may differ from the initial estimate and our seller can provide you with all the necessary information. Thank you for your interest in our product.
| Overview | |
catalog | abs134988 |
| Other names | P19Rik (6030405P19Rik) is a gene that is also known as AI429776 or B830038C02Rik. It is responsible for encoding a protein called brain and reproductive organ expressed (TNFRSF1A modulator). This protein is primarily expressed in the brain and reproductive organs. Another name for this protein is brain and reproductive organ-expressed protein. It is a subunit of the BRCA1 A complex known as BRCA1-A complex subunit BRE. Additionally, it is also a component of the BRCA1/BRCA2-containing complex, specifically BRCA1/BRCA2 containing complex subunit 4 or BRCA1/BRCA2 containing complex subunit 45. In scientific literature, this protein is often referred to as BRCC4 or BRCC45. Its gene symbol is bre and it is commonly known as BRE_HUMAN. To reiterate, P19Rik (6030405P19Rik), AI429776, and B830038C02Rik are all different names for the gene that encodes the brain and reproductive organ expressed (TNFRSF1A modulator) protein. This protein is involved in various complexes such as the BRCA1 A complex and the BRCA1/BRCA2-containing complex. |
| Source | Rabbit |
| Specificity | The BRE Antibody has the capability to identify the complete range of endogenous levels of BRE. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Chicken;Rabbit;Xenopus;Dog;Sheep;Bovine; |
| Antigen | BRE |
| Application | The working dilution for western blot is 1:500~1:1000, while for immunofluorescence/immunocytochemistry it is 1:100-1:500. For ELISA using peptide, the appropriate dilution is typically 1:20000-1:40000. |
| Immunogen | A synthesized peptide. |
| MW | 47 KD |
| Properties | |
Concentration | 1mg/ml |
| purification | Peptide affinity chromatography using SulfoLink™ Coupling Resin was used to purify the antiserum. The purification process was efficient and helped to remove any impurities or contaminants present in the antiserum. This ensured that the final product was of high quality and suitable for use in various applications. Overall, the use of peptide affinity chromatography was a crucial step in the production of purified antiserum. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | To maintain its quality, the product should be stored at a temperature of -20 °C for a duration of one year. It is important to prevent any instances of repeatedly freezing and thawing the product. Follow this storage instruction strictly to ensure the product's efficiency and effectiveness over time. |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831). |
| Tissue specificity | Expressed in all cell lines examined. Highly expressed in placenta. |
| Celluar localization | Cytosol;Nucleus; |
| UniPort | Q9NXR7 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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