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Rabbit Anti-BPI Polyclonal Antibody#abs136794

Description

Catalog-specification	Delivery time	USD price
abs136794-100ug	1-2 Weeks	301.0
abs136794-50ug	1-2 Weeks	201.0

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Overview
catalog	abs136794
Description	The lipopolysaccharide binding protein in question is known to be present in human neutrophil granules and has been found to possess potent bactericidal properties against gram-negative organisms. Its primary function is to bind to lipopolysaccharides, enabling it to specifically target and neutralize these dangerous molecules. Researchers studying this protein have found it to be an extremely promising candidate for new antimicrobial drug development. Its ability to destroy harmful bacteria while leaving healthy cells unharmed makes it an invaluable tool in the fight against infectious disease.
Other names	The Bactericidal Permeability-Increasing Protein, also known as BPI, is a type of protein that plays a significant role in the body's defense against bacterial infections. It belongs to the BPI fold containing family D, member 1, or BPIFD1, and is also referred to as CAP57. The recombinant BPI holoprotein, or rBPI, is a synthetic form of BPI that is used medically to treat sepsis. Its function is to increase the permeability of bacterial cell membranes, causing them to burst and die. This makes the protein bactericidal, which means it directly kills bacteria. Due to its importance in combating bacterial infections, extensive research is being done on the Bactericidal Permeability-Increasing Protein to develop new therapeutic drugs.
Source	Rabbit
Specificity	The BPI Antibody is capable of detecting the total amount of BPI present in the body. This means that it can identify the endogenous levels of this important protein. By using this antibody, researchers can gain a better understanding of how BPI functions within the body and how changes in its levels may be related to various diseases or conditions. Overall, the BPI Antibody is an important tool for studying the biology of this key protein.
Species Reactivity	Human;Rat
Antigen	BPI
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: - WB: 1:500-1:2000 - IHC: 1:50-1:200 - ELISA(peptide): 1:20000-1:40000 To maintain the original information while generating a highly similar content, you can use the following rearranged version: For Western blotting (WB), the recommended dilution range is typically 1:500 to 1:2000. This dilution ensures optimal detection of the target protein. In immunohistochemistry (IHC), it is commonly advised to use a dilution range of 1:50 to 1:200. This allows for effective visualization of the target antigen in tissue sections. For ELISA assays using peptide antigens, a dilution range of 1:20000 to 1:40000 is generally recommended. This dilution provides accurate quantification of the target peptide concentration. Please note that the dilution ranges mentioned are guidelines and may need to be optimized for specific experiments and antibodies used.
Immunogen	A synthesized peptide derived from human BPI.
MW	54kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used in the purification process of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal conditions, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated cycles of freezing and thawing.
Storage buffer	This product, Rabbit IgG in a buffer solution of phosphate, has a pH value of 7.4 with 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is recommended that you store it at a temperature of -20 °C, and it remains stable for up to 12 months from the date of receipt.
Target
Background	The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
Tissue specificity	Restricted to cells of the myeloid series.
Celluar localization	Extracellular region or secreted;Lysosome;Plasma Membrane;
UniPort	P17213