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Rabbit Anti-BCL2L2 Polyclonal Antibody#abs135812

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Description

Catalog-specification	Delivery time	USD price
abs135812-100ug	1-2 Weeks	301.0
abs135812-50ug	1-2 Weeks	201.0

Overview
catalog	abs135812
Description	This particular gene codes for a member belonging to the BCL-2 protein family. These proteins have the ability to form hetero- or homodimers, acting as regulators of both anti- and pro-apoptotic processes. When expressed in cells, this gene has been observed to protect against cell apoptosis when exposed to cytotoxic conditions. In mice studies, a related gene has been found to play a crucial role in the survival of neurons dependent on NGF (nerve growth factor) and BDNF (brain-derived neurotrophic factor). Furthermore, extensive research involving mutations and knockouts of the mouse gene has demonstrated its essential role in adult spermatogenesis. It is worth noting that alternative splicing results in the creation of multiple transcript variants for this gene. Additionally, there is also a phenomenon known as read-through transcription, where transcription occurs between this gene and the neighboring PABPN1 (poly(A) binding protein, nuclear 1) gene. This information has been provided by RefSeq in December 2010.
Other names	The protein BCL W, also known as Bcl-2-like protein 2 or Bcl2-L-2, plays a crucial role in regulating apoptosis or programmed cell death. It belongs to the Bcl-2 protein family and is involved in preventing the release of cytochrome c from mitochondria and inhibiting caspase activation. BCL W has been identified as a key regulator of cell survival and its absence may cause compromised cell viability. It is expressed in various tissues and is implicated in the regulation of cell death pathways. The gene encoding BCL W is located on human chromosome 14 and is also known as KIAA0271 or PPP1R51. Mutations in this gene have been associated with various pathologies such as cancer, neurodegenerative disorders, and autoimmune diseases. In conclusion, BCL W is a crucial protein that regulates apoptosis in cells and plays a critical role in maintaining cell viability. Its expression and function are tightly regulated and alterations in its form or function can lead to various pathological conditions.
Source	Rabbit
Specificity	The endogenous levels of total BCL2L2 can be effectively detected by the BCL2L2 Antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	BCL2L2
Application	The recommended dilutions for WB are 1:500-1:2000, for IHC are 1:50-1:200, for IF/ICC are 1:100-1:500, and for ELISA (peptide) are 1:20000-1:40000. It is important to follow these specific dilution ranges to ensure accurate results.
Immunogen	A synthesized peptide derived from human BCL2L2.
MW	21kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Tissue specificity	Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
Celluar localization	Cytosol;Extracellular region or secreted;Mitochondrion;
UniPort	Q92843

Western blot analysis of HL-60 cell lysate usingBCL2L2 antibody|Immunohistochemistry analysis of paraffin-embedded human kidney carcinoma tissue using BCL2L2 antibody.

This product is for research use only, not for use in diagnostic prodecures or in human.

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