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Rabbit Anti-BATF2 Polyclonal Antibody#abs138786

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Description

Catalog-specification	Delivery time	USD price
abs138786-100ug	1-2 Weeks	301.0
abs138786-50ug	1-2 Weeks	201.0

Overview
catalog	abs138786
Other names	ATF-like protein ATF 2, also known as BATF2, MGC20410, SARI or suppressor of AP-1 regulated by IFN, is a transcriptional factor that belongs to the basic leucine zipper family. This protein plays a crucial role in regulating gene expression by binding to DNA and controlling transcriptional activity. ATF 2 has been implicated in various cellular processes, including cell cycle progression, apoptosis, and stress responses. It is also involved in the immune response, where it helps in the regulation of cytokine production and T cell differentiation. Overall, ATF 2 is a vital transcription factor that plays essential roles in various cellular and physiological processes.
Source	Rabbit
Specificity	The BATF2 Antibody recognizes overall BATF2 protein levels present naturally in the body. By rearranging the original text information, a highly similar content can be generated.
Species Reactivity	Human
Antigen	BATF2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human BATF2.
MW	29kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is advised to store it at a temperature of -20 °C for a period of one year. It is important to keep in mind that repeated freeze/thaw cycles must be avoided to prevent any degradation of the product's integrity. Kindly follow the recommended storage conditions mentioned above to ensure the longevity of the product.
Storage buffer	This product is Rabbit IgG, which is provided in a solution of phosphate buffered saline at pH 7.4, with 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is recommended to store this product at a temperature of -20 °C and it will remain stable for a period of 12 months from the date of receipt. This information is important for customers who are interested in purchasing Rabbit IgG for research purposes. The solution composition and storage requirements help ensure optimal performance and customer satisfaction.
Target
Background	This transcription factor is part of the AP-1 family and plays a crucial role in regulating the differentiation of specialized cells within the immune system. Specifically, it is involved in the formation of CD8+ thymic conventional dendritic cells following an infection. Working in conjunction with JUN family proteins, this factor recognizes and binds to specific DNA sequences to control the expression of target genes. Recent studies have shown that it also has a selective ability to suppress the transcription of CYR61/CCN1, a gene that promotes cell proliferation. By inhibiting the downstream signals produced by CYR61, this transcription factor effectively blocks the growth and invasion of cancer cells, including those found in breast cancer, malignant glioma, and metastatic melanoma. It is believed to do so by interfering with the binding of AP-1 to the CYR61 promoter. Overall, this transcription factor plays a vital role in regulating immune system function and may hold promise as a target for cancer therapy.
Tissue specificity	By type I interferon. Down-regulated in most hepatocellular carcinoma tumorous tissues (at protein level).
Celluar localization	Nucleus;
UniPort	Q8N1L9