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Rabbit Anti-BACH2 Polyclonal Antibody#abs132840

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Description

Catalog-specification	Delivery time	USD price
abs132840-100ug	1-2 Weeks	301.0
abs132840-50ug	1-2 Weeks	201.0

Overview
catalog	abs132840
Description	A transcriptional regulator that can function as either a repressor or activator, this protein is known to bind to Maf recognition elements (MARE) and is involved in crucial roles that coordinate transcriptional activation and repression via MAFK.
Other names	BACH2 is an important transcription factor known as Basic leucine zipper transcription factor 2, also referred to as Bach2 or BACH2_HUMAN. This protein plays a crucial role in regulating gene expression. It belongs to the BTB and CNC homolog family, specifically BTB and CNC homology 1 basic leucine zipper transcription factor 2. This transcription factor contains a BTB domain and is homologous to BTBD25. It is encoded by the OTTHUMP00000016867, OTTHUMP00000016868, and OTTHUMP00000040591 genes. BACH2 acts as a transcription regulator, controlling the activity of various genes involved in essential cellular processes. Rearranged content: BACH2, also known as Basic leucine zipper transcription factor 2, or Bach2, is a critical protein involved in gene regulation. It falls under the BTB and CNC homolog family, specifically BTB and CNC homology 1 basic leucine zipper transcription factor 2. This transcription factor possesses a BTB domain and shares similarities with BTBD25. It is encoded by the genes OTTHUMP00000016867, OTTHUMP00000016868, and OTTHUMP00000040591. BACH2 functions as a transcription regulator, exerting control over various genes responsible for vital cellular processes.
Source	Rabbit
Specificity	The BACH2 antibody has the ability to recognize the total amount of endogenous BACH2 in a sample. The content generated should be based on this information, but rearranged using different words and sentence structure.
Species Reactivity	Human;Mouse;Rat
Antigen	BACH2
Application	The dilution ratios for Western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC) range from 1:50 to 1:200, and for ELISA (peptide) range from 1:20000 to 1:40000. These dilution ranges are essential for conducting accurate and reliable experiments in molecular biology and research. Adjusting the dilution appropriately is crucial to ensure optimal detection sensitivity and specificity. Dilution ratios play a significant role in determining the appropriate concentration of the primary antibody to achieve reliable and accurate results.
Immunogen	A synthesized peptide.
MW	93 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out by peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the storage temperature remains at -20 °C for a duration of one year, without subjecting it to multiple freezing and thawing cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity).
Tissue specificity	B-cell specific.
Posttranslational modification	Phosphorylation at Ser-521 downstream of the PI-3K pathway promotes nuclear export.The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses.
Celluar localization	Cytosol;Nucleus;
UniPort	Q9BYV9