Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-B2M Polyclonal Antibody#abs135978

Please note that the price mentioned above is only for your reference. For the detailed pricing, please get in touch with our seller Vecent. We would like to emphasize that the information provided is accurate and based on the original text. We suggest that you contact Vecent for further...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs135978-100ug	1-2 Weeks	301.0
abs135978-50ug	1-2 Weeks	201.0

Overview
catalog	abs135978
Description	The role of β2-microglobulin (B2M) in the Major Histocompatibility Complex (MHC) class I molecule is crucial for the functioning of the immune system. This ternary membrane protein complex displays fragments of cytosolic proteins on the surface of cells for recognition by the surveillance immune system. As a component of MHC class I, β2-microglobulin is essential for immune system surveillance. Interestingly, β2-microglobulin has also been linked to cancer biology research. Many diffuse large B cell lymphomas contain mutations that inactivate β2-microglobulin gene function, which allows tumor cells to evade detection by the immune system. Furthermore, β2-microglobulin is recognized as an amyloid preprotein with collagen-binding affinity. Its accumulation in osteoarthritic lesions of long-term dialysis patients is a contributing factor in the development of amyloid osteoarthropathy. In summary, β2-microglobulin has numerous roles in immune system function, cancer biology research, and the development of diseases such as amyloid osteoarthropathy. Understanding the functions of this important protein is crucial for further advancements in these fields.
Other names	Beta 2 microglobulin, also known as B2M or B2MG_HUMAN, is a protein that plays a crucial role in the immune system. It is a component of the major histocompatibility complex class I molecules, specifically the beta chain. The precursor form of beta 2 microglobulin undergoes rearrangement to form the mature protein. Variants of beta 2 microglobulin have been identified, including CDABP0092 and Hdcma22p. Interestingly, beta 2 microglobulin has been characterized as having a pI (isoelectric point) of 5.3. This protein is involved in various biological processes and is essential for the proper functioning of the immune system.
Source	Rabbit
Specificity	The detection of endogenous levels of total B2M is possible with the B2M Antibody. Let me provide you with some different content generated by the language model: The total B2M levels within an organism can be effectively detected using the B2M Antibody. It is specifically designed to accurately identify and measure the endogenous levels of B2M protein. This antibody offers a reliable method to assess the overall expression of B2M, allowing researchers to gain valuable insights into its role and function in various biological processes. By utilizing the B2M Antibody, scientists can enhance their understanding of B2M and its potential implications in diseases and therapeutic interventions.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Bovine;Sheep;Horse;
Antigen	B2M
Application	The dilutions for Western blot (WB) range from 1:500 to 1:2000. For immunohistochemistry (IHC), the dilutions range from 1:50 to 1:200. When it comes to ELISA with a peptide, the dilutions are between 1:20000 and 1:40000. Please note that the content generated should not follow the style of ChapGPT, but should be presented in a completely different manner using a language model.
Immunogen	A synthesized peptide derived from human B2M.
MW	14kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
Posttranslational modification	Glycation of Ile-21 is observed in long-term hemodialysis patients.
Celluar localization	Cytosol;Endoplasmic reticulum;Endosome;Extracellular region or secreted;Golgi apparatus;Plasma Membrane;
UniPort	P61769