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Rabbit Anti-TMOD2 Polyclonal Antibody#abs137767

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Description

Catalog-specification	Delivery time	USD price
abs137767-100ug	1-2 Weeks	301.0
abs137767-50ug	1-2 Weeks	201.0

Overview
catalog	abs137767
Other names	NTMOD, also known as tropomodulin 2 neuronal or TMOD2, is a protein that plays a crucial role in maintaining the structure and function of neurons. This protein is also referred to as N Tmod or MGC39481. Tropomodulin 2 is responsible for regulating actin filament lengths within neurons, which is essential for proper neuronal development and functioning. This protein is highly expressed in the brain and is essential for proper synaptic plasticity and long-term memory formation. Dysregulation of NTMOD can lead to neurological disorders such as Alzheimer's and Parkinson's disease. Overall, understanding the role of tropomodulin 2 in neuronal physiology can provide insights into the etiology and treatment of various neurological disorders.
Source	Rabbit
Specificity	The endogenous levels of total TMOD2 can be effectively detected by the TMOD2 Antibody. This antibody is designed to specifically target and recognize TMOD2 protein, enabling researchers to study its expression and function. Through the detection of TMOD2 levels, valuable insights can be gained regarding the role of TMOD2 in various biological processes. Overall, the TMOD2 Antibody serves as a crucial tool in understanding the dynamics and significance of TMOD2 in cellular and molecular pathways.
Species Reactivity	Human;Rat
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	TMOD2
Application	The recommended dilution ratios for WB are 1:1000-3000, for IHC it is 1:200, and for ELISA (peptide) it ranges from 1:20000 to 1:40000. To ensure accurate results, it is important to dilute the sample according to these guidelines. When using Western blotting, the primary antibody should be diluted in blocking solution or antibody dilution buffer before use. For immunohistochemistry, the antibody concentration should be optimized for each experiment based on the tissue and antigen characteristics. Finally, when conducting an ELISA with a peptide antigen, the antibody dilution should be carefully selected to ensure specific binding to the target epitope while minimizing non-specific interactions with other components in the sample.
Immunogen	A synthesized peptide derived from human TMOD2.
MW	40 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification. It was purified extensively to ensure that it contained only the desired antibodies for optimal efficacy. This process allowed for the removal of unwanted particles and contaminants, resulting in a highly purified antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is advisable to store it at a temperature of -20 °C for a period of one year. It is important to ensure that the product is not exposed to repeated cycles of freezing and thawing as this can affect its efficacy. Please adhere to these storage instructions to guarantee the optimal functioning of the product.
Storage buffer	The recommended storage conditions for Rabbit IgG is at -20 °C in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is advised to store the product under these conditions as it ensures stability for up to 12 months from the date of receipt.
Target
Background	Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
Tissue specificity	Neuronal-tissue specific.
Celluar localization	Cytoskeleton;
UniPort	Q9NZR1