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Rabbit Anti-IPMK Polyclonal Antibody#abs133661

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Description

Catalog-specification	Delivery time	USD price
abs133661-100ug	1-2 Weeks	301.0
abs133661-50ug	1-2 Weeks	201.0

Overview
catalog	abs133661
Other names	IPMK_HUMAN is a versatile enzyme that plays a crucial role in the cellular metabolism of inositol polyphosphates. Also known as inositol 1,3,4,6 tetrakisphosphate 5 kinase or Inositol 1, this enzyme catalyzes the conversion of inositol 1,3,4,6-tetrakisphosphate to inositol hexakisphosphate. This process involves the transfer of a phosphate group from ATP to inositol 1,3,4,6-tetrakisphosphate. IPMK is a multikinase that targets other inositol polyphosphates as well, including inositol 1,4,5-trisphosphate, inositol 1,4-bisphosphate, and inositol 1,3,4-triphosphate. Its activity is critical for healthy cellular processes ranging from gene expression to ion channel regulation. 3; 4; 6-tetrakisphosphate 5-kinase is another name for IPMK_HUMAN, which highlights its ability to phosphorylate inositol 3,4,6-trisphosphate.
Source	Rabbit
Specificity	To determine the levels of total IPMK, the IPMK Antibody is used. It specifically detects endogenous IPMK present in the sample. By utilizing this antibody, researchers can accurately measure the amount of IPMK protein in cells or tissues.
Species Reactivity	Human;Mouse;Rat
Antigen	IPMK
Application	The recommended dilution for Western Blot is between 1:500 to 1:1000, while for Immunofluorescence (IF) or Immunocytochemistry (ICC) it is suggested to dilute the samples at a ratio of 1:100 to 1:500. For ELISA with peptide detection, a dilution range of 1:20000 to 1:40000 is recommended. It is important to note that these dilutions can provide optimal results for the respective assays based on the original text information.
Immunogen	A synthesized peptide.
MW	47 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it is advised to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the item to multiple freeze and thaw cycles as it may have a detrimental effect.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of the product is guaranteed for a period of 12 months from the date of receipt. Please ensure that these storage conditions are followed to maintain the quality and efficacy of the Rabbit IgG.
Target
Background	This particular inositol phosphate kinase exhibits a considerably broad substrate specificity, though it appears to have a particular preference for two specific substrates - inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Its ability to effectively catalyze reactions with such a diverse range of substrates make it a particularly intriguing enzyme to study and understand. Despite this, it is clear that this inositol phosphate kinase is extremely selective when it comes to the type of phosphates it utilizes in order to perform its functions.
Tissue specificity	Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.
Celluar localization	Nucleus;
UniPort	Q8NFU5