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Rabbit Anti-ALKBH7 Polyclonal Antibody#abs138594

Please note that the provided price is for your guidance only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent. Western blot analysis ALKBH7 using Jurkat whole cell lysates This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs138594-100ug	1-2 Weeks	301.0
abs138594-50ug	1-2 Weeks	201.0

Please note that the provided price is for your guidance only. For detailed pricing information, we kindly request you to get in touch with our seller, Vecent.

Overview
catalog	abs138594
Other names	Spermatogenesis-associated protein 11, also known as ALKBH7 or ABH7, is a probable alpha-ketoglutarate-dependent dioxygenase that plays a crucial role in repairing alkylated DNA. This protein is encoded by the SPATA11 gene and is involved in the process of cell proliferation, specifically in spermatogenesis. Additionally, it is associated with the MGC10974 and UNQ6002/PRO34564 genes, which are also implicated in spermatogenesis. Overall, ALKBH7 is an essential protein that plays a critical role in maintaining genomic integrity and ensuring proper cellular function.
Source	Rabbit
Specificity	The ALKBH7 Antibody is capable of identifying total ALKBH7 at natural levels in cells. To create a similar description, the message could be expressed as follows: The detection of endogenous levels of total ALKBH7 is made possible by the ALKBH7 Antibody, which is able to accurately identify this protein in cells.
Species Reactivity	Human;Mouse;Monkey
Predictive reaction species	Pig;Sheep;Dog;Bovine;Horse
Antigen	ALKBH7
Application	IHC 1:200, WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000. It is important to note that the dilutions mentioned are based on the original text information. However, we should avoid using the content generated by ChapGPT and instead focus on generating text in a completely different manner using a language model.
Immunogen	A synthesized peptide derived from human ALKBH7.
MW	24 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. Our process resulted in a highly purified product that met our standards for use in our applications.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid exposing the product to repeated freeze/thaw cycles as this can affect its stability over time. Please make sure that you follow these guidelines carefully to ensure that the product remains effective and reliable for its intended use.
Storage buffer	This product comprises Rabbit IgG dissolved in phosphate buffered saline (pH 7.4), containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this at a temperature of -20 °C. The stability of the product is guaranteed for a period of 12 months starting from the date of receipt.
Target
Background	May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).
Tissue specificity	Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
Celluar localization	Mitochondrion;
UniPort	Q9BT30