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Rabbit Anti-ALKBH2 Polyclonal Antibody#abs138593

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Description

Catalog-specification	Delivery time	USD price
abs138593-100ug	1-2 Weeks	301.0
abs138593-50ug	1-2 Weeks	201.0

Overview
catalog	abs138593
Other names	ALKBH2, also known as alkB alkylation repair homolog 2, is a protein encoded by the ALKBH2 gene in humans. It is an important enzyme involved in the repair of alkylated DNA damage. The protein belongs to the alpha-ketoglutarate-dependent dioxygenase family and plays a vital role in oxidative demethylation of DNA. One particular variant of ALKBH2, known as 2OG Fe(II) oxy DC1, with the reference number 9530023G02, has been extensively studied. This variant exhibits similar functions as the wild-type ALKBH2 protein. ALKBH2 is crucial for maintaining genomic stability by repairing DNA damage caused by alkylating agents. It has been implicated in DNA repair processes and is thought to be involved in preventing mutations and genomic rearrangements that can lead to various diseases, including cancer. The ALKBH2 protein is characterized by its dependency on alpha-ketoglutarate, which serves as a cofactor for its enzymatic activity. As an alpha-ketoglutarate-dependent dioxygenase, ALKBH2 utilizes molecular oxygen to catalyze the oxidative demethylation of alkylated DNA bases. The gene encoding ALKBH2 is also referred to as ABH2, and it shares homology with the alkB gene, which was originally discovered in bacteria. The ALKBH2 protein has a conserved domain structure similar to other alkB homologs. In summary, ALKBH2, or alkB alkylation repair homolog 2, is an essential component of the cellular machinery responsible for repairing alkylated DNA damage. Its role in maintaining genomic integrity makes it a crucial target for further research in the field of DNA repair and its implications in various diseases.
Source	Rabbit
Specificity	The ALKBH2 Antibody is capable of detecting the levels of total ALKBH2 present in the organism. It specifically targets endogenous ALKBH2, providing accurate results. By rearranging the content, we can say that the antibody is designed to identify the total ALKBH2 levels in the body, ensuring that it only detects endogenous ALKBH2.
Species Reactivity	Human;Mouse
Predictive reaction species	Dog
Antigen	ALKBH2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human ALKBH2.
MW	29kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography process to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is essential to avoid subjecting the product to repeated cycles of freezing and thawing.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
Tissue specificity	Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.
Celluar localization	Cytoskeleton;Nucleus;
UniPort	Q6NS38