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Rabbit Anti-ALB Polyclonal Antibody#abs135916

Please note that the price mentioned above is for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller Vecent. Western blot analysis of extracts of mouse livercell lines, using ALB antibody. This product is for research use only, not for...

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Description

Catalog-specification	Delivery time	USD price
abs135916-100ug	1-2 Weeks	301.0
abs135916-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is for your reference only. For detailed pricing information, we kindly request you to get in touch with our seller Vecent.

Overview
catalog	abs135916
Description	The liver is primarily responsible for synthesizing serum albumin, which is the most abundant protein found in plasma. With a concentration of approximately 40 g/L, albumin constitutes over 50% of the total protein content in human plasma. Its crucial role lies in its capacity to act as a major transporter for various endogenous and exogenous compounds such as fatty acids, steroid hormones, metabolites, and drugs. By fulfilling this transportation function, albumin facilitates the movement of essential substances throughout the body. Additionally, albumin plays a vital role in maintaining colloid osmotic pressure, which is crucial for the proper functioning of the microvasculature. Therefore, this multifaceted protein not only contributes to the transportation of vital compounds but also influences microvascular integrity. (1)
Other names	ALBU_HUMAN is an abbreviation for alb, which stands for Albumin. Albumin is a protein consisting of 32 amino acids. It plays a vital role in various physiological processes in the human body. One particular variant of Albumin, known as Albumin (AA 34), has a slight alteration in its amino acid sequence. This modification does not significantly affect its function. Aside from its primary function as a carrier protein, Albumin is associated with certain medical conditions. Analbuminemia is a disorder characterized by a decreased level or absence of Albumin in the blood. On the other hand, Bisalbuminemia refers to a condition where there are two different types of Albumin present in the bloodstream. Another interesting protein related to Albumin is Cell Growth Inhibiting Protein 42. This protein has been found to have inhibitory effects on cell growth activities. Additionally, there is a genetic marker called DKFZp779N1935 associated with the Albumin gene. Dysalbuminemic hyperthyroxinemia is a condition where there is an abnormal increase in thyroid hormone levels due to alterations in Albumin. Growth Inhibiting Protein 20 is another protein that belongs to the Albumin family and is involved in regulating cell growth. HSA is the common abbreviation used for Human Serum Albumin, referring to Albumin found in blood plasma. It serves various functions like maintaining osmotic pressure and transporting hormones, drugs, and fatty acids. Lastly, PRO0883, PRO0903, and PRO1341 are protein identifiers, commonly used in research studies and databases to uniquely identify specific forms of Albumin or related proteins. In summary, Albumin is a crucial protein in the human body, with various variants and associations with medical conditions. Understanding its functions and genetic markers can provide valuable insights into human physiology and potential therapeutic interventions.
Source	Rabbit
Specificity	Endogenous levels of total ALB can be accurately detected by the ALB Antibody. Here's an alternative way to express the same information: The ALB Antibody is capable of identifying the endogenous levels of total ALB with great precision.
Species Reactivity	Human;Mouse;Rat
Antigen	ALB
Application	For Western Blotting, the recommended dilution range is between 1:500-1:2000. Meanwhile, for Immunohistochemistry, dilution ranges between 1:50-1:200 are advised. In ELISA with peptides, a dilution of 1:20000-1:40000 is highly recommended. These dilution ranges have been carefully tested and determined to provide optimal results for the respective assays. It's important to follow the recommended dilution ranges to ensure accurate and effective experiments.
Immunogen	A synthesized peptide derived from human ALB.
MW	69kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum. An effective purification method was implemented to refine the antiserum using the mentioned resin.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.
Tissue specificity	Plasma.
Posttranslational modification	Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.Glycated in diabetic patients.Phosphorylated by FAM20C in the extracellular medium.Acetylated on Lys-223 by acetylsalicylic acid.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;Golgi apparatus;Nucleus;
UniPort	P02768