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Rabbit Anti-AIFM2 Polyclonal Antibody#abs138156

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Description

Catalog-specification	Delivery time	USD price
abs138156-100ug	1-2 Weeks	301.0
abs138156-50ug	1-2 Weeks	201.0

Overview
catalog	abs138156
Other names	AIFM2 (5430437E11Rik) is also known as AIFM2_HUMAN or AMID. It is a protein associated with mitochondria called Apoptosis Inducing Factor (AIF) that induces cell death. It is similar to another protein called Apoptosis Inducing Factor-like mitochondrion-associated inducer of death. AIFM2 is also referred to as Apoptosis-inducing factor homologous mitochondrion-associated inducer of death. It is encoded by the AIFM2 gene. In addition, AIFM2 is associated with other names such as Apoptosis-inducing factor 2 and Apoptosis-inducing factor-like mitochondrion-associated inducer of death. There is a variation of AIFM2 known as Cys51Stop. It is classified under the HGNC11998 gene. AIFM2 is also related to p53-responsive gene 3 (PRG3) and is a part of the p53 tumor suppressor pathway. To summarize, AIFM2 is a protein involved in apoptosis induction and is associated with mitochondria. It is connected to various names and pathways, including the p53 tumor suppressor pathway.
Source	Rabbit
Specificity	The total amount of endogenous AIFM2 can be detected by using the AIFM2 antibody. You can create similar content by rearranging the original text information and emphasizing the detection of the overall levels of AIFM2 in the sample.
Species Reactivity	Human;Mouse
Antigen	AIFM2
Application	The recommended dilutions for using the WB technique range from 1:1000 to 3000, while for the IF/ICC technique they range from 1:100 to 1:500. If you prefer conducting ELISA assays using peptide, then the recommended dilutions are between 1:20000 and 1:40000. By rearranging the original content, we have provided you with the same information in a different format so that you can better understand the dilution ranges for these three techniques.
Immunogen	A synthesized peptide derived from human AIFM2.
MW	40 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the product's quality, it is recommended that you store it at a temperature of -20°C for up to one year. It is important to avoid any repeated freeze and thaw cycles to ensure that the product remains stable and effective. Please make sure to follow the storage instructions carefully to maximize the shelf life of the product.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.
Tissue specificity	Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells.
Celluar localization	Cytosol;Extracellular region or secreted;Mitochondrion;
UniPort	Q9BRQ8