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Rabbit Anti-AGPAT5 Polyclonal Antibody#abs140720

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Description

Catalog-specification	Delivery time	USD price
abs140720-100ug	1-2 Weeks	301.0
abs140720-50ug	1-2 Weeks	201.0

Overview
catalog	abs140720
Other names	epsilon acyltransferase, also known as acylglycerol 3 phosphate O acyltransferase 5 or AGPAT5, is an important enzyme involved in lipid metabolism. It catalyzes the transfer of an acyl group from an acyl-CoA donor molecule to the sn-1 position of lysophosphatidic acid (LPA), forming phosphatidic acid (PA). This enzymatic reaction is a critical step in the biosynthesis of glycerophospholipids, which are essential constituents of cell membranes and play vital roles in various cellular processes. The gene encoding epsilon acyltransferase is designated as AGPAT5 and is located on human chromosome X. This enzyme exhibits substrate specificity towards LPA and utilizes different acyl-CoA species as acyl donors, leading to the generation of various phospholipid species with different fatty acyl compositions. The activity of epsilon acyltransferase is tightly regulated to maintain lipid homeostasis and ensure proper cellular function. Epsilon acyltransferase is widely expressed in different tissues and cell types, indicating its importance in lipid metabolism and cellular physiology. Dysregulation of this enzyme has been implicated in various pathological conditions, including metabolic disorders, cardiovascular diseases, and cancer. Therefore, epsilon acyltransferase represents a potential therapeutic target for the development of novel drugs aimed at modulating lipid metabolism and treating related diseases. In conclusion, epsilon acyltransferase, also known as AGPAT5 or LPAAT epsilon, is an enzyme involved in the biosynthesis of glycerophospholipids. It plays a crucial role in lipid metabolism and cellular physiology, and its dysregulation is associated with various diseases. Further research on this enzyme may provide insights into its therapeutic potential and contribute to the development of new treatment strategies.
Source	Rabbit
Specificity	The total AGPAT5 levels can be detected by the AGPAT5 Antibody, which specifically targets the endogenous AGPAT5 protein. Engaging in a distinct approach, I will now generate content that maintains the underlying information from the original text.
Species Reactivity	Human
Antigen	AGPAT5
Application	1:500~1:1000，IF/ICC1:100-1:500。（ELISA）1:20000-1:40000。，。
Immunogen	A synthesized peptide.
MW	45 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl-CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable.
Tissue specificity	Widely expressed.
Celluar localization	Endoplasmic reticulum;Mitochondrion;Nucleus;
UniPort	Q9NUQ2