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Rabbit Anti-AGPAT3 Polyclonal Antibody#abs140721

Description

Catalog-specification	Delivery time	USD price
abs140721-100ug	1-2 Weeks	301.0
abs140721-50ug	1-2 Weeks	201.0

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Overview
catalog	abs140721
Other names	Gamma acyltransferase is an enzyme that plays a significant role in lipid metabolism. It is also known as 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma or 1-acylglycerol-3-phosphate O-acyltransferase 3. This enzyme is responsible for the transfer of acyl groups to lysophosphatidic acid (LPA), which is a precursor in the synthesis of various phospholipids. Commonly referred to as AGPAT3 or LPAAT-gamma, this enzyme participates in the biosynthesis of triglycerides, phospholipids, and other lipid molecules. Its activity ensures the proper functioning of cellular membranes and helps regulate lipid homeostasis. The gene encoding the gamma acyltransferase in humans is PLCC_HUMAN or UNQ759/PRO1490. It encodes a specific protein that exhibits acyltransferase activity, enabling the formation of acyl-CoA from LPA. Understanding the mechanisms and functions of gamma acyltransferase is crucial for comprehending lipid metabolism and its implications in various physiological and pathological processes. Further research on this enzyme can potentially unravel new insights into lipid-related disorders and pave the way for the development of therapeutic interventions.
Source	Rabbit
Specificity	The AGPAT3 Antibody is capable of detecting total AGPAT3 levels present in the body. These levels are not artificially induced, but rather are naturally occurring in the body. The antibody is accurate in detecting endogenous levels, providing reliable results for research and lab purposes. Overall, the AGPAT3 Antibody is a valuable tool for evaluating the presence of AGPAT3 in biological samples.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig
Antigen	AGPAT3
Application	For Western blotting, a dilution of 1:500 to 1:1000 is recommended. For immunofluorescence/immunocytochemistry, a dilution of 1:100 to 1:500 is suggested. For ELISA using a peptide substrate, a dilution of 1:20000 to 1:40000 is appropriate. It is important to note that these dilutions may need to be optimized for specific experimental conditions.
Immunogen	A synthesized peptide.
MW	40 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, we recommend keeping the product at a temperature of -20 °C for a period of one year. To prevent any damage to the product, it is important to avoid exposing it to repeated freeze and thaw cycles. This will help to maintain the quality and effectiveness of the product over time.
Storage buffer	Phosphate buffered saline, pH 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol is the storage solution for Rabbit IgG. It is recommended to store this solution at -20 °C. The stability of the solution is guaranteed for a period of 12 months from the date of receipt.
Target
Background	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (PubMed:21173190). Has a preference for arachidonoyl-CoA as a donor. Has also a modest lysophosphatidylinositol acyltransferase (LPIAT) activity, converts lysophosphatidylinositol (LPI) into phosphatidylinositol (By similarity).
Tissue specificity	Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver.
Celluar localization	Endoplasmic reticulum;Golgi apparatus;Nucleus;Plasma Membrane;
UniPort	Q9NRZ7