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Rabbit Anti-PSMD11 Polyclonal Antibody#abs140722

Description

Catalog-specification	Delivery time	USD price
abs140722-100ug	1-2 Weeks	301.0
abs140722-50ug	1-2 Weeks	201.0

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Overview
catalog	abs140722
Other names	There are several names for the protein 26S proteasome non-ATPase regulatory subunit 11, including 26S proteasome regulatory subunit 9, 26S proteasome regulatory subunit p44.5, 26S proteasome regulatory subunit RPN6, 26S proteasome regulatory subunit S9, MGC3844, p44.5, protease 26S subunit 9, and proteasome 26S subunit non-ATPase 11. This protein plays a crucial role in the regulation and degradation of key cellular proteins, and is involved in various cellular pathways. As such, understanding its function and structure is of great importance to unlocking new therapeutic targets for diseases such as cancer. By rearranging these various names and descriptions, a fuller understanding of this protein can be achieved.
Source	Rabbit
Specificity	The PSMD11 Antibody is specifically designed to target and detect total PSMD11 levels present in the natural cellular environment. By using this antibody, researchers can accurately measure the endogenous levels of PSMD11 protein. It provides a valuable tool for studying the functions and regulations of PSMD11 in various biological processes.
Species Reactivity	Human;Mouse
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	PSMD11
Application	：WB 1:500~1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000。。，，。，。
Immunogen	A synthesized peptide.
MW	42 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we employed peptide affinity chromatography to purify the antiserum. The resulting product was carefully purified, ensuring high levels of similarity to the original blood sample.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated cycles of freezing and thawing.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Tissue specificity	Highly expressed in embryonic stem cells (ESCs). Expression decreases as ESCs differentiate.
Posttranslational modification	Phosphorylated by AMPK.
Celluar localization	Cytosol;Extracellular region or secreted;Nucleus;
UniPort	O00231