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Rabbit Anti-ACSL5 Polyclonal Antibody#abs139127

Description

Catalog-specification	Delivery time	USD price
abs139127-100ug	1-2 Weeks	301.0
abs139127-50ug	1-2 Weeks	201.0

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Overview
catalog	abs139127
Other names	Acyl CoA synthetase 5, also known as ACS2 or Fatty acid Coenzyme A ligase 5, is a member of the long chain acyl CoA synthetase family. This enzyme plays a vital role in fatty acid metabolism by aiding in the conversion of fatty acids into their CoA derivatives. The FACL5 gene encodes for the ACS5 protein, which is mainly expressed in tissues that actively synthesize and degrade fatty acids. The ACS5 protein is involved in critical metabolic pathways, including beta-oxidation, lipid biosynthesis, and triglyceride metabolism. In summary, ACS5 is a significant enzyme that has been implicated in various metabolic processes in the body, making it a potential target for therapeutic interventions in lipid-related disorders.
Source	Rabbit
Specificity	The endogenous levels of total ACSL5 can be identified using the AC5L5 Antibody. The antibody is specifically designed to recognize and detect the presence of ACSL5 in biological samples. By targeting the total ACSL5 protein, this antibody enables researchers to study and analyze the expression and localization of ACSL5 in various tissues and cell types. Its specificity and sensitivity make it a valuable tool in exploring the role of ACSL5 in different physiological and pathological conditions. The AC5L5 Antibody offers a reliable means to investigate the regulation and function of ACSL5, contributing to a better understanding of its involvement in cellular metabolism and lipid metabolism disorders.
Species Reactivity	Human;Mouse;Rat
Antigen	ACSL5
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human ACSL5.
MW	76kDa
Properties
Concentration	1mg/ml
purification	Peptide affinity chromatography using SulfoLink™ Coupling Resin was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing. Taking these measures will help ensure the product remains in optimal condition for an extended period of time.
Storage buffer	The storage conditions for the rabbit IgG are as follows: it should be kept in a solution of phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. The recommended storage temperature is -20°C, and the product should be stable for up to 12 months from the date of receipt.
Target
Background	Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
Celluar localization	Endoplasmic reticulum;Mitochondrion;Nucleus;
UniPort	Q9ULC5