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Phospho-SGO1 (Ser14) Rabbit Polyclonal Antibody#abs140140

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Description

Catalog-specification	Delivery time	USD price
abs140140-100ug	1-2 Weeks	301.0
abs140140-50ug	1-2 Weeks	201.0

Overview
catalog	abs140140
Other names	There are several proteins that are commonly referred to as SGO 1 or its various aliases, such as Shugoshin 1AB, CD, EF, GH, and KL proteins. In addition, another possible reference to SGO 1 is as NY BR 85 or Serologically defined breast cancer antigen NY-BR-85. These proteins are all relevant in different contexts and the specific reference to SGO 1 can depend on the particular field of research or clinical application. Nonetheless, they all share a similar function in chromosome segregation and the maintenance of chromosome stability during cell division. Furthermore, there is also a related protein called Shugoshin-like 1 or Shugoshin like 1 (S. pombe), which may be involved in similar cellular processes. Overall, the diverse names and designations for SGO 1 reflect the ongoing efforts to understand and characterize its multifaceted roles in the cell.
Source	Rabbit
Specificity	The SGO1 (Phospho-Ser14) Antibody specifically recognizes the presence of endogenous SGO1 protein when it is phosphorylated at Ser14. Hence, the detectable signal of this antibody is directly proportional to the phosphorylation level of SGO1 at Ser14.
Species Reactivity	Human
Predictive reaction species	Rabbit;Pig;Dog;Horse;Bovine
Antigen	SGO1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	SGO1（Ser14），，。
MW	64kDa
Properties
Concentration	1mg/ml
purification	Sequential chromatography was used to purify the antibody from rabbit serum, specifically through affinity purification on phospho- and non-phospho-peptide affinity columns. The purified antibody was obtained through this process.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure maximum shelf life, it is recommended to store this product at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to repeated cycles of freezing and thawing, as this can compromise its quality. Whether you are storing the product for personal or commercial use, following these guidelines will help ensure that it remains effective and safe to use.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.
Tissue specificity	Widely expressed. Highly expressed in testis. Expressed in lung, small intestine, breast, liver and placenta. Strongly overexpressed in 90% of breast cancers tested.
Posttranslational modification	Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1.Phosphorylation by NEK2 is essential for chromosome congression in mitosis and for the proper attachment of spindle microtubule to the kinetochore. Phosphorylated by PLK1 and AUKRB.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q5FBB7