Phospho-IKK-gamma (Ser85) Rabbit Polyclonal Antibody#abs131121

abs131121-50ug

1-2 Weeks

201

abs131121-100ug

1-2 Weeks

301

Description

Incontinentia pigmenti (IP) is a familial disorder that is characterized by an X-linked dominant inheritance pattern. It primarily affects females and can lead to a wide range of abnormalities in the skin, hair, nails, teeth, eyes, and central nervous system. Unfortunately, for males, it is typically lethal before birth. The International Incontinentia Pigmenti Consortium conducted a study in 2000 that shed light on the nature of this condition (PubMed 10839543). It is important to note that this content has been rearranged for a highly similar version to the original text while retaining the essential information.

Other names

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Source

Rabbit

Specificity

The presence of phosphorylated IKK-γ at Serine 85 can be accurately determined using the Phospho-IKK-γ (Ser85) Antibody. This antibody is specifically designed to detect endogenous levels of IKK-γ only when it is phosphorylated at Serine 85. By targeting this specific phosphorylation site, the antibody allows for precise detection and analysis of IKK-γ activation.

Application

WB1:500-1:2000，IF/ICC1:100-1:500，ELISA(peptide)1:20000-1:40000。，。

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One could consider developing a peptide that is synthetically derived from the region around the phosphorylation site of Serine 85 on human IKK-γ. Such a peptide would resemble the natural structure and composition of IKK-γ in that specific area. By focusing on this phosphorylation site, researchers could explore potential therapeutic applications or study the biological functions associated with Serine 85 phosphorylation. It is crucial to develop a highly similar peptide to ensure accurate representation of the original IKK-γ molecule and facilitate more precise investigations.

Properties

1mg/ml

Purification

Affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns was employed to purify the antibody, which originated from purified rabbit serum. Let me generate a highly similar content based on the original text information.

Clonality

Polyclonal Antibody

To maintain optimum conditions, store the item at a temperature of -20 °C for a duration of one year. It is crucial to prevent the occurrence of repeated freeze/thaw cycles.

Storage buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

 Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

Tissue specificity

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Celluar localization

Cytoskeleton;Cytosol;Nucleus;

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