Phospho-Ephrin B1/B2/B3 (Tyr324) Rabbit Polyclonal Antibody#abs138257
Please note that the price provided is for your reference only. For detailed pricing information, kindly contact our seller, Vecent. We recommend reaching out to Vecent for accurate pricing details. Western blot analysis Phospho-Ephrin B1/B2/B3 (Tyr324) using NIH-3T3 whole cell lysates This...
Description
| Catalog-specification | Delivery time | USD price |
abs138257-100ug | 1-2 Weeks | 301.0 |
abs138257-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is for your reference only. For detailed pricing information, kindly contact our seller, Vecent. We recommend reaching out to Vecent for accurate pricing details.
| Overview | |
catalog | abs138257 |
| Other names | Craniofrontonasal syndrome (CFNS) is a genetic disorder that is characterized by abnormal development of the craniofacial region. It is caused by mutations in the EFNB1 gene, which codes for a protein called Ephrin-B1. EFNB1 mutations can lead to a wide range of symptoms, including craniofacial abnormalities, such as a high forehead, wide-set eyes, and a cleft lip or palate. Other features of CFNS can include skeletal abnormalities, such as webbed neck and fused fingers or toes, as well as intellectual disability. CFNS is an X-linked disorder, which means it primarily affects females, while males may have milder symptoms or be unaffected. Genetic testing can be used to confirm a diagnosis of CFNS. Treatment for CFNS is based on managing the specific symptoms and may involve a multidisciplinary approach with medical specialists from various fields. |
| Source | Rabbit |
| Specificity | The Phospho-Ephrin B1/B2/B3 (Tyr324) Antibody is specifically designed to detect the presence of Ephrin B1/B2/B3 proteins in their phosphorylated state at Tyr324. This antibody is capable of differentiating between the endogenous levels of Ephrin B1/B2/B3 when they are phosphorylated at Tyr324 and when they are not. By specifically targeting this phosphorylation site, the antibody provides a reliable means of studying the activation and signaling pathways of Ephrin B1/B2/B3 proteins. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | Ephrin B1/B2/B3 |
| Application | IHC 1:200, IF/ICC 1:100-1:500, WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000. It is important to note the recommended dilutions for various laboratory techniques. For Western blot (WB), a dilution range of 1:1000-3000 is typically used. Immunohistochemistry (IHC) requires a dilution of 1:200, while for immunofluorescence/immunocytochemistry (IF/ICC), the recommended dilution range is 1:100-1:500. ELISA assays using peptides as antigens usually require a higher dilution, between 1:20000-1:40000. These dilution factors ensure optimal detection and labeling of the target molecules in experimental settings. |
| Immunogen | A peptide has been synthesized from the human Phospho-Ephrin B1/B2/B3 (Tyr324) sequence. To create a similar content, we can mention that the synthesized peptide is derived from the aforementioned human protein sequence. The peptide has been accurately crafted to closely resemble the original sequence in terms of its amino acid composition and structure. The peptide is likely to exhibit similar biological activity to the original protein, which has been shown to be involved in various cellular processes such as cell adhesion and migration. This synthesized peptide could have potential therapeutic applications in the future for diseases where the activity of Phospho-Ephrin B1/B2/B3 is perturbed. |
| MW | 38 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). |
| Tissue specificity | Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas. |
| Posttranslational modification | Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. |
| Celluar localization | Extracellular region or secreted;Nucleus;Plasma Membrane; |
| UniPort | P98172/P52799/Q15768 |
Western blot analysis Phospho-Ephrin B1/B2/B3 (Tyr324) using NIH-3T3 whole cell lysates
This product is for research use only, not for use in diagnostic prodecures or in human.
Hot Tags: phospho-ephrin b1/b2/b3 (tyr324) rabbit polyclonal antibody#abs138257, China phospho-ephrin b1/b2/b3 (tyr324) rabbit polyclonal antibody#abs138257 suppliers
Send Inquiry
You Might Also Like
