Trimetazidine Dihydrochloride

Trimetazidine dihydrochloride, an effective medication for angina pectoris, acts as a cytoprotective anti-ischemic agent. Its unique mechanism of action involves enhancing the utilization of glucose by the heart muscle while inhibiting the metabolism of fatty acids. This groundbreaking drug offers significant benefits in improving the overall function of the myocardium. By targeting the underlying metabolic abnormalities associated with angina, trimetazidine dihydrochloride offers a promising approach to managing this challenging cardiovascular condition.

99%

，-20℃。
To maintain the stability of your solution, it is recommended to store it in DMSO or other solvents at a temperature of 2-4° C for up to two weeks and at a temperature of -20° C for up to six months. These storage conditions will ensure that your solution remains usable and effective for longer periods, allowing you to make the most of your resources. It is important to keep your solution in a safe and controlled environment to prevent any potential degradation or loss of efficacy. By following these guidelines for storage, you can help ensure optimal results from your solution.

DMSO : 67 mg/mL (197.49 mM)

Water : 67 mg/mL (197.49 mM)

Ethanol : 67 mg/mL (197.49 mM)

mitochondrial long-chain 3-ketoacyl thiolase

Trimetazidine up-regulates miR-21 expression, then miR-21 targets PTEN increasing the PI3K pathway and finally the activation of this pathway counteracts the apoptotic effect of hypoxia/reperfusion.

The administration of TMZ reduces myocardial infarction size in WT C57BL/6J hearts. Both AMPK and ERK signaling pathways mediate the cardioprotection of TMZ against ischemic injury. Trimetazidine Shifts Metabolism from Fatty Acid Oxidation to Glucose Oxidation and improves Contractile Functions of Cardiomyocytes during Hypoxia.

• 1. Kantor PF, et al. Circ Res. 2000 Mar 17;86(5):580-8.

• 2. Stanley WC, Marzilli M. Fundam Clin Pharmacol. 2003 Apr;17(2):133-45.

• 3. Sellier P, Broustet JP. Am J Cardiovasc Drugs. 2003;3(5):361-9.