Artesunate

Artesunate, belonging to the artemisinin group of agents, exhibits a potent IC50 of less than 5 μM against the H69 small cell lung carcinoma cell line. This compound, derived from artemisinin through semi-synthesis, possesses water solubility, enabling its administration via injection. Although primarily utilized for malaria treatment, artesunate has also exhibited remarkable efficacy, surpassing 90%, in reducing egg production caused by Schistosoma haematobium infection.

＞98%

store at -20° C for one year（Powder）；
To preserve your substances in DMSO or other solvents, it's important to store them properly. The best option is to refrigerate them at 2-4° C for no longer than two weeks. If a longer storage time is required, the substances should be frozen at -20° C for up to six months. Following these guidelines will help ensure the longevity and potency of your materials.

DMSO : 71 mg/mL (184.7 mM)

Ethanol : 71 mg/mL (184.7 mM)

EXP1(a membrane glutathione S-transferase),STAT3

The use of ART in the treatment of glioma cells presents potential benefits in disrupting their biomechanical properties and suppressing their proliferation, migration and invasion abilities. This is achieved through the induction of apoptosis and cell cycle arrest at the G0/G1 phase in SKM-1 cells. Mechanistically, ART works by elevating intracellular calcium ion concentration and ROS levels. Additionally, ART can regulate the expressions of BCL-2/BAX ratio and P-bad and survivin proteins, thus promoting the pro-apoptotic activity of the drug. Furthermore, ART can reverse the DNA methylation of CDH1, thereby activating E-cadherin in SKM-1 cells. These findings provide important insights into the potential use of ART as a therapeutic agent for the treatment of glioma cells and MDS.

Artesunate is a medication used to treat malaria. Artesunate can induce radiosensitivity of HeLa cells in vivo using Xenograft model of nude mice. Artesunate had a relatively high immunosuppressive activity with low toxicity, and could inhibit T lymphocyte proliferation induced by mitogen and alloantigen.