Arbidol Hydrochloride

＞98%

store at -20℃ for one year（Powder）；
To ensure optimal storage conditions for your substance dissolved in DMSO or other solvents, it is recommended to store it at 2-4℃ for up to two weeks or at -20℃ for up to six months. Following this recommended storage protocol can help preserve the integrity and stability of your substance, ensuring it remains effective for its intended use.

Soluble in DMSO

Influenza Virus

Arbidol exhibits a dose-dependent inhibition of HCV pseudoparticles entry, effectively targeting genotypes 1a, 1b, and 2a. It also displays dose-dependent inhibition of HCV membrane fusion, as demonstrated by the use of fluorescent liposomes and HCV pseudoparticles (HCVpp). Furthermore, Arbidol demonstrates potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14, and CVB3. This antiviral effect is observed when Arbidol is administered before, during, or after viral infection, with IC50 values ranging from 2.7 to 13.8 mg/mL.
Regarding its selective antiviral activity, Arbidol specifically targets AdV-7, a DNA virus, but only when administered after infection (therapeutic index (TI) = 5.5). In the context of influenza A/PR/8/34 infection, Arbidol induces changes in viral mRNA synthesis of genes PB2, PA, NP, NA, and NS when cultured in MDCK cells.
In terms of its mechanism of action, Arbidol interacts with and modifies the physicochemical properties of membrane phospholipids. It has a significant impact on negatively charged phospholipids, while exerting a minor effect on zwitterionic phospholipids. Specifically, Arbidol localizes at the membrane interface and engages in hydrogen bonding with water and phospholipids. This interaction leads to a disruption of the hydrogen bonding network among phospholipids, resulting in a phospholipid phase that resembles a dehydrated solid structure.
Additionally, Arbidol exhibits potent inhibitory activity against HTNV when administered either before or after viral infection in vitro, with IC50 values of 0.9 mg/mL and 1.2 mg/mL, respectively.