Tryptamine

Tryptamine, a monoamine alkaloid, can be found in various organisms such as plants, fungi, and animals. Possessing an indole ring structure, it derives its name from the amino acid tryptophan due to its structural resemblance. Although present in small quantities in mammals' brains, tryptamine is believed to serve as a neuromodulator or neurotransmitter, playing a significant role.

＞98%

store at -20° C for one year（Powder）；
To ensure optimal storage conditions for DMSO or other solvents, it is recommended to store them at 2-4° C for a period of two weeks. Alternatively, if longer storage is required, it is recommended to store them at a temperature of -20° C for a period of up to six months. These storage guidelines help to maintain the stability and integrity of the solvent, ultimately ensuring its effectiveness when in use.

DMSO : ≥ 150 mg/mL (936.21 mM)

hTAAR1

Autophagy can be triggered in nerve cells and astrocytes through the presence of high concentrations (0.1-1 mM) of tryptamine. Primary cultures of astrocytes appear to be less sensitive to this process than neurons. This suggests a potential role for tryptamine in the regulation of autophagy in the nervous system.

The inhibition of locomotor activity is observed when mice are administered tryptamine intraperitoneally at a dose of 50 mg/kg. On the other hand, peculiar behaviors such as head twitch, head weaving, forepaw treading, hindlimb abduction, and Straub tail are induced by tryptamine at doses ranging from 150 to 300 mg/kg. The effects of tryptamine on mouse behavior can be both depressive and excitatory, depending on the dosage. The excitatory behaviors induced by tryptamine are thought to be caused by its direct stimulation of 5-HT receptors and facilitation of 5-HT release.