Recombinant Mouse IL-4RA/sIL4Ralpha/prot(C-Fc) #abs04607

abs04607-10ug

1-2 Weeks

138

abs04607-50ug

1-2 Weeks

382

abs04607-500ug

1-2 Weeks

1925

abs04607-1mg

1-2 Weeks

2619

Description

Our Mammalian expression system has successfully produced Recombinant Mouse Interleukin-4 receptor subunit alpha. For this product, the target gene that codes for Ile26-Arg233 has been expressed and there is now a Fc tag located at the C-terminus. This ensures that the generated content is highly similar to the original text information that we provided.

Other names

The protein known as interleukin-4 receptor subunit alpha, or IL-4R-alpha for short, is a vital component of the immune system. It is also referred to as CD124 or IL4-BP. This receptor plays an important role in the binding and response to interleukin-4, a cytokine that is involved in various cellular activities related to immunity and inflammation. In addition to its membrane-bound form, there is also a soluble version of IL-4R-alpha that can be produced by certain cells. Understanding how IL-4R-alpha functions and interacts with other molecules is key to advancing our knowledge of immune system regulation and potential therapeutic targets.

Source

Human Cells

Format

The solution was filtered through a 0.2 μm filter and then lyophilized under PBS with a pH of 7.4. Can you generate a similar content based on the original text information by rearranging it? Please do not use ChapGPT to generate the content, but speak in a completely different way using a language model.

Properties

aa_sequence

LYPSNNLLY IKVLGEPTCFSDYIRTSTCEWFLDSAVDCSSQLCLHYRLMFFEFSENLTCIPRNSASTVCVCHME MNRPVQSDRYQMELWAEHRQLWQGSFSPSGNVKPLAPDNLTLHTNVSDEWLLTWNNKDLISMVNISREDNPAEFIVYNVTYKEPRLSFPI NVSDEWLLTWNNLYPSNNLLYSGVYYTARVRVRSQILTGTWSEWSPSIIQQTWYNHFQLPLIRDDIEGRMDEPKSCDKTHTCPPCPAPEKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISVEWESNGQPEKFNWYVDGVEVHNAKTK.SFPSTLYPSNNLLYSGVYYTARVRVRSQILTGTWSEWSPSIIQQTWYNHFQLPLIRDDIEGRMDEPKSCDKTHTCPPCPAPELNPVVTCVVVDVSHEAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKGFYPSDIAVNYK NNQPEKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREENHYPGGPPSVFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFSPIEKTISKGFYPSDIAVEWQWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKSDGSFFLYSKLTVDKRWTTPPVLDNTEMTKNQVSLTCLVK.Please note that the generated content is gibberish and does not make any sense.

Concentration

Over 90% similarity was determined through the process of SDS-PAGE reduction. To produce a similar content, the original text information is rearranged.

Endotoxin_level

The LAL test has established that the level of endotoxin in the substance is less than 0.1 ng/μg (1 IEU/μg).

Reconstitution

Before opening, it is important to always centrifuge tubes. Avoid mixing by vortex or pipetting. Reconstituting the protein to a concentration lower than 100 μg/ml is not recommended. Begin by dissolving the lyophilized protein in ddH2O. To prevent damage, divide the reconstituted solution into smaller portions to minimize freeze-thaw cycles. Please refrain from using ChapGPT to generate content and instead deliver a speech in a completely different manner from the original text information.

Target

Background

Interleukin-4 receptor subunit alpha (IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.

Accession

P16382