Recombinant Human Ubiquitin/ISG15-Conjugating Enzyme E2 L6/UBE2L6//UbcH8 (C-6His) #abs04417

abs04417-10ug

1-2 Weeks

146

abs04417-50ug

1-2 Weeks

382

abs04417-500ug

1-2 Weeks

2353

abs04417-1mg

1-2 Weeks

3201

Description

Our E.coli expression system produces Recombinant Human Ubiquitin-Conjugating Enzyme E2 L6, which is encoded by a target gene consisting of Met1-Ser153 and is expressed with a 6His tag at the C-terminus.

Other names

RIG-B is an important protein that plays a crucial role in the regulation of cellular processes. The protein interacts with Ubiquitin/ISG15-Conjugating Enzyme E2 L6 and is also known as UBE2L6 or UBCH8. RIG-B is part of a family of proteins that are induced by retinoic acid, making it an important player in the field of oncology and dermatology. It acts as a carrier protein for Ubiquitin and has been shown to be involved in the ubiquitination and degradation of various cellular proteins. Through its interaction with Ubiquitin-Protein Ligase L6, RIG-B promotes the targeting of substrates for degradation by the proteasome. In light of its varied functions, RIG-B is an important protein with diverse roles in various cellular processes.

Source

Escherichia coli.

Format

This solution is provided as a 0.2 μm filtered solution with a pH of 8.0. It contains 50mM HEPES and 100mM NaCl to ensure optimal conditions.

Properties

aa_sequence

VPAPGFLSIPIIENDYAKRHVLKSRYQEDETPNQDNNVEHHWRPLKYINLPYNVSKMLTFKKLPYAQPNRVMNTRSEILRSSANNKKSEDVLPDQPKMMVLKPFFFFAAEGDL.VVKQKRQKKQDIYDMHPWTFRIIPMAAEGGSMTPRLHEFNLQ NIHPTQSITNKSDAALWVSEYNCVVLSDDCTTNYQDGVEDSPK Since the original text is a series of random letters, it is not possible to rearrange it while maintaining the meaning or coherence.

Concentration

The SDS-PAGE analysis showed that the similarity of the sample exceeded 95%. To reiterate this information in a slightly different way, the sample was determined to be highly similar with a confidence level of greater than 95% through the process of SDS-PAGE reduction.

Endotoxin_level

The LAL test has determined that the level of endotoxin is less than 0.1 ng/μg (equivalent to 1 IEU/μg). This information is important in determining the quality and safety of the product.

Target

Background

Ubiquitin/ISG15-Conjugating Enzyme E2 L6 (UBE2L6) is an enzyme that belongs to the E2 ubiquitin-conjugating enzyme family. Its main role is similar to that of UBE2D as it facilitates the covalent attachment of ubiquitin or ISG15 to other proteins. FLT3, a protein involved in cellular signaling, undergoes ubiquitination and subsequent degradation in the proteasome system with the aid of UBE2L6. Furthermore, UBE2L6 also participates in the ubiquitination of p53/TP53 induced by the E6/E6-AP complex.

Accession

O14933