Recombinant Human Interleukin-13 Receptor Subunit Alpha-1/IL-13RA1(C-6His) #abs04584

abs04584-10ug

1-2 Weeks

77

abs04584-50ug

1-2 Weeks

161

abs04584-500ug

1-2 Weeks

917

abs04584-1mg

1-2 Weeks

1382

Description

Our advanced Mammalian expression system enables us to produce Recombinant Human Interleukin-13 Receptor Subunit Alpha-1, with a target gene encoding Gly22-Thr343 and a 6His tag located at the C-terminus. This ensures unparalleled purity and quality in our product.

Other names

IL-13 receptor subunit alpha-1, also known as IL-13R-alpha-1 or IL13RA1, is a protein that plays a key role in the body's immune system response. This receptor subunit is a component of the receptor complex for interleukin-13, a cytokine that is involved in various physiological processes, including inflammation, allergy, and the regulation of immune cells. IL-13R-alpha-1 is expressed on a variety of cell types, including immune cells, epithelial cells, and neural cells. In addition to its role in immunity, IL-13R-alpha-1 has also been implicated in cancer development and progression. Cancer/testis antigen 19, or CT19, is an alternate name for IL-13R-alpha-1, indicating its potential as a target for cancer immunotherapy. CD213a1 is another name for this protein, reflecting its classification as a member of the CD213 antigen family. Overall, IL-13R-alpha-1 is a critical component of the body's immune defense system and a potential target for cancer treatment.

Source

Human Cells

Format

pH 7.4, lyophilized from a solution of PBS that has been filtered through a 0.2 μm filter. Let's create a similar content by rephrasing the provided information.

Properties

aa_sequence

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Concentration

The purity of the sample was assessed by reducing SDS-PAGE and found to be greater than 95%. To rephrase this, it can be said that following the analysis of reduced SDS-PAGE, it was determined that the sample had a purity of over 95%.

Endotoxin_level

The LAL test has determined that the content is less than 0.1 ng/μg (1 IEU/μg). Can you provide a paraphrased version of this?

Activity

TF-1 human erythroleukemic cells' IL-13-dependent proliferation is effectively inhibited by the substance with an ED50 of roughly 13.9 ng/mL.

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target

Background

Interleukin-13 receptor subunit alpha-1 (IL13RA1) is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. The human IL13-Rα1 was originally cloned based on sequence homology to the mouse IL13-Rα1, it share 76% aa sequence identity. Human The IL13-Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. The extracellular domain of IL13-Rα1 is also closely related to that of IL13-Rα2. It binds with low affinity to interleukin-13 (IL13). IL13RA1 serves as a primary IL13- binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.

Accession

P78552