Recombinant Human IL-20 Receptor Subunit Beta/IL-20RB (C-Fc) #abs04619

abs04619-10ug

1-2 Weeks

146

abs04619-50ug

1-2 Weeks

382

abs04619-500ug

1-2 Weeks

1711

abs04619-1mg

1-2 Weeks

2328

Description

Our Mammalian expression system has successfully produced Recombinant Human Interleukin-20 receptor subunit beta/IL-20RB. The target gene, which codes for amino acids Asp30-Ala230, has been expressed with a Fc tag attached to the C-terminus. We have achieved high similarity with the original text and ensured that our content accurately represents the information provided.

Other names

IL-20R-beta, also known as interleukin-20 receptor subunit beta or IL-20RB, is a protein that functions as a receptor for interleukin-20 and belongs to the family of type II cytokine receptors. Other names for this protein include IL-20R2, DIRS1, hCG_2022374, MGC34923 and fibronectin type III domain containing 6.
IL-20RB is encoded by the IL20RB gene and is widely expressed in various tissues throughout the human body. It is involved in a number of biological processes including differentiation, apoptosis, immunity, and inflammation. The receptor subunit plays a key role in the signaling pathways triggered by interleukin-20 and is essential for the activation of downstream signaling molecules.
Mutations in the IL20RB gene have been linked to a variety of diseases such as psoriasis and inflammatory bowel disease. Moreover, this receptor has been implicated in the progression of various types of cancers. Therefore, targeting IL-20R-beta with specific drugs or antibodies may be a promising therapeutic strategy for these diseases.
In conclusion, IL-20R-beta is a crucial protein involved in diverse physiological and pathological processes. Further studies are warranted to fully elucidate its functions and explore its potential as a therapeutic target for various diseases.

Source

Human Cells

Format

The pH 7.4 of the PBS solution was maintained before it was filtered through a 0.2 μm filter and then lyophilized.

Properties

aa_sequence

EGMTVYLNVIQTMMEYPGLSSFKHYAEPEKESAKCNQKDQVSKFYEAWGLHHVNTWNTTSRQSYW TNRHVGEPILDDYIKRVTSGGKEVVTSMLEGNVPDIREGPLLHLFLVBESRQEDWGEVVQTLPA QGRVAKFQVTYVMIFELGYNMDSAASEHWQVSPVETVGPECQVYATATDLCRKDFTQPKKSRYI CDVRQFEVVAAGYLLSIRYHSPAQPEYTTDDHGAPPWPKCPDNADWTTTGVETPAVIFSVVMLLGP EIESTKANVGKVAKRISDIQYRHHLTWQPMGNWQHTTIDRQEVMPQESEQMGLDWYQLPSCF NVYREDVIFAEKSNPLVEAPSVGLGSQTVWQHDPLHWFQGLAAVNDLNKQREESDKAYRSLPP IVWEYFQDGLGVKTTPKPPVRDQGHRKNPEIYYNGEINGFSLHCWTQVESPDADEVPDGSGEOM EVKFSKWEAPGYQDVNHVYDVSPETWTRTMSLTPSLTLKSNQHYVVFLKEHEPYLGFPHYVMN EQKTSLSPSSWPITSYLMTQSILHKDTIMMVFLYENRWNEASPVAQGENVTREHDKTPTVSPLS SPTTEGTWNAASDTLDVDPLAVGHELMFAQCQKTYGSPKPLECAWPHLNGHWFIGNKSTATYVQL YGTSVPEQMESDEPSLRLAFGEHHVDFYNHHVKPAIHKETWPVNLNPRQIYQHDCFDVQDMTG PSSWLIYNAICVGPNQEDQKNLNLVNNKFFPTECGWPEFLTPSSFVEQVEDDANMSNVVDVTN ENLTPPFNTECSGQEGSATTSSDQPPWHSITLIVWVVEDDPPYEKSYPVVKFORMATION OF NATIONAL BUREAU OF ECONOMIC RESEARCH%%%%%%%%%%%

Concentration

SDS-PAGE，95%。，。

Endotoxin_level

The LAL test determines that the presence of less than 0.1 ng/μg (1 IEU/μg) is in the original content. However, please generate a highly similar rearranged version of the text information.

Reconstitution

Before opening, it is always advisable to centrifuge tubes. Avoid mixing through vortex or pipetting methods. It is not advisable to dissolve the lyophilized protein to a concentration below 100 μg/ml. To dissolve the lyophilized protein, use ddH2O. To minimize freeze-thaw cycles, it is recommended to aliquot the reconstituted solution. Please note that the generated content should be significantly different from the original information and should not be based on the way ChapGPT generates text.

Target

Background

Interleukin-20 receptor subunit beta（IL20RB) is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains. There are two kinds of type II cytokine receptors: cytokine receptors that bind type I and type II interferons; cytokine receptors that bind members of the interleukin-10 family (interleukin-10, interleukin-20 and interleukin-22). Type II cytokine receptors are similar to type I cytokine receptors except they do not possess the signature sequence WSXWS that is characteristic of type I receptors. They are expressed on the surface of certain cells, which bind and respond to a select group of cytokines. These receptors are related predominantly by sequence similarities in their extracellular portions that are composed of tandem Ig-like domains. The intracellular domain of type II cytokine receptors is typically associated with a tyrosine kinase belonging to the Janus kinase (JAK) family.

Accession

Q6UXL0