Recombinant Human Mast/stem Cell Growth Factor Receptor Kit/CD117/c-kit (C-6His) #abs04620

abs04620-10ug

1-2 Weeks

115

abs04620-50ug

1-2 Weeks

344

abs04620-500ug

1-2 Weeks

1375

abs04620-1mg

1-2 Weeks

1819

Description

Our Mammalian expression system produces the Recombinant Human Mast/stem Cell Growth Factor Receptor Kit, which expresses the target gene encoding Gln26-Thr520 with a 6His at the C-terminus. In order to generate a highly similar content, the provided information can be rearranged as follows: The Recombinant Human Mast/stem Cell Growth Factor Receptor Kit is produced using our Mammalian expression system. This kit includes the target gene encoding Gln26-Thr520, with a 6His tag at the C-terminus.

Other names

The Kit protein, also known as Mast/Stem Cell Growth Factor Receptor Kit or SCFR, is a transmembrane receptor tyrosine kinase. It is encoded by the KIT gene and plays a critical role in the regulation of hematopoiesis, gametogenesis, melanogenesis, and mast cell differentiation.
Piebald trait protein or PBT is another name for Kit, due to the association between Kit mutations and the piebald trait in certain mammalian species, including mice and horses. The proto-oncogene c-Kit was originally identified as a viral oncogene, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.
As a tyrosine-protein kinase, Kit is involved in cellular signaling pathways that control cell growth, differentiation, migration, and survival. It is expressed in a variety of different cell types, including stem cells, melanocytes, germ cells, and mast cells. Kit is also involved in the development and maintenance of the gastrointestinal tract, skin, and neural crest-derived cells.
CD117 is the human cell membrane receptor encoded by the KIT gene. It is often used as a marker for the identification and isolation of hematopoietic stem and progenitor cells. Mutations in the KIT gene have been linked to various disorders, including gastrointestinal stromal tumors, mastocytosis, and leukemia. Therefore, Kit is an important molecular target for cancer therapy.

Source

Human Cells

Format

The content was obtained by filtering a solution of PBS, pH 7.4, which was then lyophilized.

Properties

aa_sequence

Here's a rephrased version of the original text:
The sequence of letters QPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEAT NTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKP LPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKAS YLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDS GVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIY MNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEI LTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTHHHHHH can be rearranged to read differently, while still conveying the same information.
One possible rephrased version could be:
The string of characters QPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEAT NTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKP LPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKAS YLLREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDS GVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIY MNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEI LTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTHHHHHH can be rearranged into a different sequence of letters that still imparts the same meaning.

Concentration

The level of purity was found to be over 95% by using SDS-PAGE analysis. It is possible to create similar content by rearranging the original text information and presenting it in a new way.

Endotoxin_level

The LAL test has determined that the level of endotoxins present is less than 0.1 ng/μg or equivalent to 1 IEU/μg. This information reveals low levels of contamination and indicates that the product meets the required standards for quality and safety.

Reconstitution

Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target

Background

C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. Mature human SCF R consists of a 499 amino acid (aa) extracellular domain (ECD) with five tandem immunoglobulinlike domains, a 21 aa transmembrane segment, and a 431 aa cytoplasmic domain with the split tyrosine kinase domain. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-or Th17-biasing stimuli, and it is required for subsequent dendritic cell induction of Th2 and Th17 responses. SCF R protects vascular smooth muscle cells from apoptosis and assists in the recovery of cardiac function following myocardial infarction.

Accession

P10721