Recombinant Human IL-17 Receptor A/IL-17RA/CD217 (C-Fc) #abs04089

abs04089-10ug

1-2 Weeks

77

abs04089-50ug

1-2 Weeks

230

abs04089-500ug

1-2 Weeks

993

abs04089-1mg

1-2 Weeks

1237

Description

Our Mammalian expression system produces Recombinant Human Interleukin-17 receptor A, with a target gene that codes for Leu33-Trp320 and features a Fc tag situated at the C-terminus. To create a comparable variation, we suggest rearranging the given information to form a fresh take on the original text.

Other names

IL-17 receptor A is also known as IL-17RA, CDw217, CD_antigen, CD217, IL17RA, or IL17R. This receptor is involved in the interleukin-17 signaling pathway. IL-17RA plays a crucial role in mediating the inflammatory response and immune system regulation. It is essential for the activation of various downstream signaling cascades that contribute to the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and psoriasis. The multiple names and aliases associated with IL-17RA reflect its significance and widespread recognition in scientific literature and research.

Source

Human Cells

Format

The substance was dehydrated through a process of lyophilization from a solution consisting of PBS with a pH level of 7.4. Prior to this, the solution was filtered with a 0.2 μm filter to ensure particle-free clarity.

Properties

aa_sequence

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Concentration

The SDS-PAGE reduction technique revealed a protein purity level of more than 95%. To provide similar information using a different structure and wording, it can be said that the protein sample analyzed displayed a high level of purity, as evidenced by its SDS-PAGE profile indicating a percentage of over 95%.

Endotoxin_level

The LAL test has determined that the level of endotoxin in the sample is less than 0.1 ng/μg (1 IEU/μg). This indicates a very low level of endotoxin present in the sample.

Activity

The ability to suppress IL-6 secretion in NIH-3T3 mouse embryonic fibroblast cells when stimulated by IL-17 is used as a measure. The effective dose (ED50) required for this inhibition is less than 100 ng/ml. It is important to create unique and distinct content instead of rearranging the original text information.

Reconstitution

Before opening tubes, it's important to always centrifuge them. Mixing should not be done using vortex or pipetting. Reconstituting protein to a concentration less than 100 μg/ml is not recommended. Use ddH2O to dissolve the lyophilized protein. To minimize freeze-thaw cycles, it's best to aliquot the reconstituted solution. It's advisable to rephrase this information in a similar manner to the original text, without using ChapGPT as a guide.

Stability & Storage

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target

Background

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure.

Accession

Q96F46