Succinate Dehydrogenase Microplate Assay Kit

Succinate dehydrogenase (ubiquinone), also known as succinic dehydrogenase or complex II (ambiguous), is an enzyme that plays a crucial role in energy production. It is a part of the succinate dehydrogenase complex, also referred to as SDH or succinate:ubiquinone oxidoreductase. This enzyme helps in the conversion of succinate to fumarate during the citric acid cycle. Its activity is dependent on the presence of ubiquinone, a coenzyme that transfers electrons within the electron transport chain. Through its catalytic function, succinate dehydrogenase contributes to the generation of ATP, the main energy currency in cells.

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Measuring the activity of succinate dehydrogenase is crucial for understanding cellular processes such as respiration and energy metabolism. To achieve this, detection and quantification methods have been developed, enabling researchers to determine the levels of activity in various biological samples.
These methods involve the use of spectrophotometry or fluorometry to measure changes in absorbance or fluorescence over time, respectively. By monitoring the conversion of succinate to fumarate, the activity of succinate dehydrogenase can be calculated using the values obtained from these instruments.
Additionally, other methods such as in situ hybridization and immunohistochemistry can be utilized to localize succinate dehydrogenase and assess its cellular distribution. These techniques provide further insights into the role of this enzyme in various tissues and organs.
Overall, the detection and quantification of succinate dehydrogenase activity are essential for advancing our understanding of fundamental biological processes and for identifying potential therapeutic targets for various diseases.

4 μmol/L - 400 μmol/L

Shipped and store at 4°C for 6 months.