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Rabbit Anti-ZEB2 Polyclonal Antibody#abs131374

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Description

Catalog-specification	Delivery time	USD price
abs131374-100ug	1-2 Weeks	301.0
abs131374-50ug	1-2 Weeks	201.0

Overview
catalog	abs131374
Description	A transcriptional inhibitor with the ability to bind to the DNA sequence 5'-CACCT-3' has been discovered in multiple promoters. This specific inhibitor has been found to effectively repress the transcription of E-cadherin. By targeting the 5'-CACCT-3' DNA sequence, it exerts its inhibitory effect on the transcriptional activity of E-cadherin, thereby modulating gene expression. This finding is significant as it provides a potential avenue for studying the regulation and control of E-cadherin expression, potentially leading to new therapeutic strategies for related diseases and disorders.
Other names	There are several different names for the protein encoded by the ZEB2 gene. It is also known as FLJ42816, HSPC082, KIAA0569, SIP 1, SMADIP 1, SMADIP1, ZEB 2, Zeb2, ZFHx1b, ZFHX1B protein, Zfx1b, Zinc finger E box binding protein 2, Zinc finger E-box-binding homeobox 2, Zinc finger homeobox 1b, and zinc finger homeobox protein 1. Regardless of the name, ZEB2 is a critical protein involved in various cellular functions. As a Smad-interacting protein 1, it plays a role in modulating the activity of the Smad signaling pathway. Meanwhile, as a zinc finger homeobox protein, it can function as a transcriptional regulator that helps control gene expression in response to different signals. Overall, ZEB2 represents an important protein with diverse functions and roles in cellular biology.
Source	Rabbit
Specificity	The ZEB2 Antibody is capable of detecting total ZEB2 levels that are present naturally in the body. A content that mainly replicates the information provided in the original text can be generated by restructuring the given text.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Sheep;Dog;Horse;
Antigen	ZEB2
Application	The working dilution range for western blot (WB) is 1:500-1:2000. For immunohistochemistry (IHC), it is 1:50-1:200. When it comes to immunofluorescence/immunocytochemistry (IF/ICC), the recommended dilution range is 1:100-1:500. For ELISA using peptides, the appropriate dilution range would be 1:20000-1:40000. Please note that the generated content will be based on the original text information but in a different format or arrangement, as requested.
Immunogen	A synthesized peptide derived from human ZEB2.
MW	136 kDa.
Properties
Concentration	1mg/ml
purification	We conducted purification of the antiserum through peptide affinity chromatography by employing SulfoLink™ Coupling Resin. This process was aimed at achieving high levels of purity for the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.
Posttranslational modification	Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.
Celluar localization	Cytosol;Nucleus;
UniPort	O60315