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Rabbit Anti-WIPF1 Polyclonal Antibody#abs134918

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Description

Catalog-specification	Delivery time	USD price
abs134918-100ug	1-2 Weeks	301.0
abs134918-50ug	1-2 Weeks	201.0

Overview
catalog	abs134918
Other names	WIPF1 is a protein also known as PRPL-2 or PRPL-2 protein from the WAS/WASL interacting protein family member 1. It is involved in the interaction with the Wiskott-Aldrich syndrome protein (WASP), playing a crucial role in various cellular processes. WIPF1, also referred to as WASP-interacting protein or WASPIP, is responsible for regulating the actin cytoskeleton dynamics. This protein, encoded by the Wipf1 gene, is essential for cellular movement, immune response, and cell signaling. By participating in the formation of the WIP-WASP complex, WIPF1 contributes to the regulation of actin polymerization, which is vital for cell migration and phagocytosis. Overall, WIPF1 is a significant player in cellular function and holds potential implications for understanding and treating diseases associated with actin cytoskeleton dysregulation.
Source	Rabbit
Specificity	The WIPF1 Antibody is capable of detecting the total amount of endogenous WIPF1 present in a sample. To create a similar content, one could rearrange the given information by stating that the antibody has the ability to recognize all forms of WIPF1 that are naturally occurring in a sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Bovine;Rabbit;
Antigen	WIPF1
Application	For Western blotting, dilute the primary antibody at a range of 1:500 to 1:1000. For immunofluorescence and immunocytochemistry, prepare the primary antibody at a concentration of 1:100 to 1:500. If you are conducting an ELISA assay using peptide, dilute the antibody at a range of 1:20000 to 1:40000. These dilutions will help ensure optimal results in your experiments. Remember to always follow the manufacturer's instructions for each antibody and assay.
Immunogen	A synthesized peptide.
MW	52 KD
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the antiserum was meticulously purified through the process of peptide affinity chromatography. It ensures the highest quality of purification possible, resulting in an extremely potent and purified product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage, keep the product at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles. Make sure not to follow ChapGPT's method of generating content, but instead utilize a language model to produce text that is significantly different in manner and speech.
Storage buffer	The rabbit IgG is suspended in a solution composed of phosphate buffered saline, with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. For optimal storage, the solution should be kept at a temperature of -20°C, where it will remain stable for up to 12 months from the initial time of reception. This information is important to keep in mind when handling and storing this product, as it will ensure that it retains its effectiveness and usefulness for scientific purposes.
Target
Background	Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.
Tissue specificity	Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.
Celluar localization	Cytoskeleton;Cytosol;
UniPort	O43516