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Rabbit Anti-VEGFB Polyclonal Antibody#abs131346

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Description

Catalog-specification	Delivery time	USD price
abs131346-50ug	1-2 Weeks	201.0
abs131346-100ug	1-2 Weeks	301.0

Overview
catalog	abs131346
Description	Endothelial cell growth is enhanced by a growth factor called VEGF-B167, which interacts with heparin and neuropilin-1. On the other hand, VEGF-B186 also binds neuropilin-1, but its binding is affected by proteolysis. Thus, both variants of VEGF-B demonstrate a different mechanism of action in terms of their binding to neuropilin-1.
Other names	VEGF B, also known as Vascular Endothelial Growth Factor-Related Factor or VEGF-Related Factor, is a protein that plays a crucial role in the growth and proliferation of blood vessels. This molecule is encoded by the Vegfb gene and is involved in the regulation of vascular development, particularly during embryonic and fetal stages. In addition, VEGF B has been identified as a potential therapeutic target for the treatment of cancer and other diseases that involve abnormal blood vessel growth. Its functions and mechanisms are currently being studied in depth by the scientific community. Other aliases of VEGF B include VEGFB_HUMAN, VEGFL, and VRF.
Source	Rabbit
Specificity	The VEGFB Antibody is capable of detecting total VEGFB levels that are naturally present within the body. This antibody is effective at identifying both the endogenous and exogenous forms of VEGFB. Given this information, could you please provide additional details on the significance and applications of this antibody?
Species Reactivity	Human;Mouse;Rat
Antigen	VEGFB
Application	The dilutions for Western Blot (WB) range from 1:500 to 1:2000, for Immunohistochemistry (IHC) they are 1:50 to 1:200, and for ELISA (peptide) the dilutions are 1:20000 to 1:40000. Please note that the rearranged content is still based on the original information provided.
Immunogen	A synthesized peptide derived from human VEGFB.
MW	22 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to perform peptide affinity chromatography for purifying the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C. It is important to avoid subjecting the product to repeated cycles of freezing and thawing. It is also advisable to store the product under these conditions for a duration of one year. Please refrain from following the freezing and thawing process frequently in order to maintain the quality of the product.
Storage buffer	The Rabbit IgG solution comes in a phosphate buffered saline with a pH of 7.4 and 150mM of NaCl. The solution has 0.02% of sodium azide and 50% glycerol, which helps maintain its stability. This product should be stored at -20°C and has a shelf life of 12 months from the date of receipt. Ensure to handle the solution properly to avoid any contamination that may affect its potency.
Target
Background	Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Tissue specificity	Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Posttranslational modification	VEGF-B186 is O-glycosylated.
Celluar localization	Extracellular region or secreted;
UniPort	P49765