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Rabbit Anti-APLP1 Polyclonal Antibody#abs136567

Please note that the price mentioned is provided as a reference only. For detailed pricing information, we kindly ask you to reach out to our sales representative, Vecent. Western blot analysis of extracts of Mousebrain cell line, using APLP1 antibody. This product is for research use only, not...

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Description

Catalog-specification	Delivery time	USD price
abs136567-100ug	1-2 Weeks	301.0
abs136567-50ug	1-2 Weeks	201.0

Please note that the price mentioned is provided as a reference only. For detailed pricing information, we kindly ask you to reach out to our sales representative, Vecent.

Overview
catalog	abs136567
Description	This member of the amyloid precursor protein gene family codes for a gene that is highly conserved. It produces a glycoprotein that is associated with the cell membrane and undergoes cleavage by secretases, similar to the cleavage of the amyloid beta A4 precursor protein. This cleavage releases an intracellular cytoplasmic fragment, which has the potential to function as a transcriptional activator. Additionally, the encoded protein may contribute to the maturation of synapses during the development of the cortex. Various isoforms of this gene, resulting from alternative splicing of the transcript variants, have been identified.
Other names	One of the important proteins in the body is the Amyloid Beta A4 Precursor-Like Protein 1 (APLP1), also known as Amyloid Precursor-Like Protein or APLP. This protein is a precursor for the amyloid protein, which is believed to be involved in the development of Alzheimer's disease. APLP1 is involved in the growth and development of nerve cells in the brain, and it is also involved in the regulation of neurotransmitter signaling. It has been shown to have a protective effect on the brain, and studies have suggested that it may play a role in the prevention of neurodegenerative diseases. There is also evidence to suggest that APLP1 may be involved in the regulation of cholesterol metabolism, which is important for overall health and wellbeing. Overall, APLP1 is an important protein that plays a vital role in the functioning of the brain and the body as a whole.
Source	Rabbit
Specificity	The APLP1 Antibody has the ability to recognize total APLP1 levels in the body. This means that it can efficiently detect the presence of endogenous APLP1.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Dog;Horse
Antigen	APLP1
Application	（WB）1:500-1:2000，（IHC）1:50-1:100，（ELISA）1:20000-1:40000。，。
Immunogen	A synthesized peptide derived from human APLP1.
MW	72kD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. To ensure highly purified antiserum was obtained, this method was chosen.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Tissue specificity	Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
Posttranslational modification	Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity).N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P51693