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Rabbit Anti-VCAM1 Polyclonal Antibody#abs135602

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Description

Catalog-specification	Delivery time	USD price
abs135602-100ug	1-2 Weeks	301.0
abs135602-50ug	1-2 Weeks	201.0

Overview
catalog	abs135602
Description	Vascular cell adhesion protein 1 (VCAM1) plays a vital role in recognizing cells. It facilitates leukocyte-endothelial cell adhesion, interacts with the beta-1 integrin VLA4 on leukocytes, and transmits signals. It has two isoforms: Isoform 1, a single-pass type I membrane protein, and isoform 2, a lipid-anchor (GPI-anchor). Inflamed vascular endothelium, as well as macrophage-like and dendritic cell types in both normal and inflamed tissue, express VCAM1. Additionally, it is expressed in the bone marrow. (1)...To produce highly similar content, rephrase the above information in a different way, making sure to stick to the original text's details. Do not speak in the same fashion as ChapGPT-generated content, instead take a unique approach using the language model to generate various content.
Other names	The CD106 antigen, also known as VCAM-1 or vascular cell adhesion molecule 1, is a protein that plays a critical role in inflammation and endothelial cell activation. It is expressed on activated endothelial cells and is involved in leukocyte trafficking. CD106 is also known as L1CAM and INCAM-100, and has been identified as a potential therapeutic target for various diseases including atherosclerosis, rheumatoid arthritis, and multiple sclerosis. Its alternative names include INCAM 100, vascular cell adhesion protein 1, and V-CAM 1. With its diverse functions, CD106 remains an important area of ongoing research in the field of vascular biology and immunology.
Source	Rabbit
Specificity	The endogenous levels of total VCAM1 can be detected using the VCAM1 Antibody. To create a highly similar content by rearranging the information above, one could say: "Detecting the total VCAM1 levels present internally is possible through the utilization of the VCAM1 Antibody."
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Horse
Antigen	VCAM1
Application	The recommended dilution ratios for western blotting are 1:500-1:2000, while for immunohistochemistry it is 1:50-1:200. For ELISA using peptide as the antigen, the suggested dilution range is between 1:20000 and 1:40000. These dilution levels have been optimized for effective detection and accurate results. It is important to follow the instructions carefully and to ensure that the antibody is suitable for the intended application. With proper handling and dilution, these techniques can provide reliable and reproducible data for your research.
Immunogen	A synthesized peptide derived from human VCAM1.
MW	81kDa
Properties
Concentration	1mg/ml
purification	The use of SulfoLink™ Coupling Resin facilitated the purification of the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Tissue specificity	Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Posttranslational modification	Sialoglycoprotein.
Celluar localization	Cytoskeleton;Endoplasmic reticulum;Endosome;Extracellular region or secreted;Golgi apparatus;Plasma Membrane;
UniPort	P19320