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Rabbit Anti-TTR Polyclonal Antibody#abs135776

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Description

Catalog-specification	Delivery time	USD price
abs135776-50ug	1-2 Weeks	201.0
abs135776-100ug	1-2 Weeks	301.0

Overview
catalog	abs135776
Description	Transthyretin is one of the three prealbumins, which also includes alpha-1-antitrypsin and orosomucoid. Its main function is to act as a carrier protein, transporting thyroid hormones in the bloodstream and cerebrospinal fluid, as well as retinol (vitamin A) in the plasma. The protein comprises of a tetramer of identical subunits. This gene has been associated with over 80 different mutations, most of which are related to amyloid deposition that tends to affect the peripheral nerve and/or heart. However, a small portion of the mutations in this gene is not amyloidogenic. The diseases caused by such mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome, among others. This information was provided by RefSeq in January 2009.
Other names	There are several medical conditions that are associated with transthyretin, also known as TTR or prealbumin protein. These include amyloid polyneuropathy, commonly referred to as ATTR, as well as amyloidosis type I, senile systemic amyloidosis, and prealbumin amyloidosis type I. Additionally, transthyretin has also been linked to carpal tunnel syndrome 1, which is sometimes abbreviated as CTS or CTS1. Other rare disorders that involve transthyretin include dysprealbuminemic euthyroidal hyperthyroxinemia and dystransthyretinemic hyperthyroxinemia. Epididymis luminal protein 111, or HEL111, and HsT2651 are other names by which transthyretin may be known. Transthyretin is a thyroid hormone-binding protein that is produced primarily in the liver, and it plays an important role in transporting thyroxine throughout the body. Variations in the structure or levels of transthyretin can result in a range of different diseases and health concerns. However, researchers continue to study transthyretin and its impact on various medical conditions in order to develop new treatments and therapies.
Source	Rabbit
Specificity	Total TTR levels can be detected using the TTR Antibody, which specifically targets endogenous TTR.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Sheep;Dog;Horse;Bovine
Antigen	TTR
Application	The recommended dilution for WB is between 1:500 to 1:2000, while for IHC it is recommended to dilute at 1:50 to 1:200. In ELISA using peptide, the recommended dilution is between 1:20000 to 1:40000. It is important to follow the recommended dilution range to ensure accurate and reliable results.
Immunogen	A synthesized peptide derived from human TTR.
MW	16kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Tissue specificity	Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Posttranslational modification	Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.
Celluar localization	Extracellular region or secreted;Lysosome;
UniPort	P02766