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Rabbit Anti-LPIN1 Polyclonal Antibody#abs137401

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Description

Catalog-specification	Delivery time	USD price
abs137401-100ug	1-2 Weeks	301.0
abs137401-50ug	1-2 Weeks	201.0

Overview
catalog	abs137401
Other names	Lipin-1, also known as phosphatidate phosphatase LPIN1, is an enzyme coded by the KIAA0188 gene with the EC number 3.1.3.4. It is commonly referred to as PAP1 as well. LPIN1 is a crucial enzyme involved in the regulation of lipid metabolism and has been shown to play a role in various physiological processes, including adipogenesis, glucose homeostasis, and insulin sensitivity. Studies have also linked LPIN1 mutations to several metabolic disorders, such as type 2 diabetes, hypertriglyceridemia, and insulin resistance. Understanding the functions and dysregulation of LPIN1 may pave the way for therapeutic interventions in these metabolic diseases.
Source	Rabbit
Specificity	The LPIN1 Antibody is designed to specifically detect the total LPIN1 protein at endogenous levels. It ensures accurate identification of LPIN1 protein in samples.
Species Reactivity	Human
Antigen	LPIN1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human LPIN1.
MW	99 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to perform peptide affinity chromatography for the purification of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended to keep the product at a temperature of -20 °C for a duration of one year. It is vital to avoid subjecting the product to repetitive freeze-thaw cycles, as this may compromise its quality.
Storage buffer	This solution contains Rabbit IgG in a phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this solution at a temperature of -20°C. It has a shelf life of 12 months from the date of receipt. You can trust that this high-quality product will maintain its stability and effectiveness throughout its recommended usage period.
Target
Background	It performs vital functions in regulating fatty acid metabolism at various stages. This enzyme, dependent on magnesium, acts as a phosphatidate phosphatase, facilitating the conversion of phosphatidic acid to diacylglycerol in the endoplasmic reticulum membrane. Furthermore, it serves as a coactivator for PPARGC1A/PPARA in the nucleus, contributing to the modulation of gene expression involved in lipid metabolism. This protein also plays a role in the differentiation of adipocytes. Additionally, there is a possibility that it is involved in mitochondrial fission through the conversion of phosphatidic acid to diacylglycerol.
Tissue specificity	Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract.
Posttranslational modification	Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway. Phosphorylation is decreased by epinephrine. Phosphorylation may not directly affect the catalytic activity but may regulate the localization. Dephosphorylated by the CTDNEP1-CNEP1R1 complex (By similarity).Sumoylated.
Celluar localization	Cytosol;Endoplasmic reticulum;Mitochondrion;Nucleus;
UniPort	Q14693