Rabbit Anti-TRAF1 Polyclonal Antibody#abs131497
Please note that the price provided is only for your reference and for a detailed price, please get in touch with our seller, Vecent. It is important to understand that the aforementioned price is subject to change, and therefore, we advise you to reach out to our seller for accurate pricing...
Description
| Catalog-specification | Delivery time | USD price |
abs131497-100ug | 1-2 Weeks | 301.0 |
abs131497-50ug | 1-2 Weeks | 201.0 |
Please note that the price provided is only for your reference and for a detailed price, please get in touch with our seller, Vecent. It is important to understand that the aforementioned price is subject to change, and therefore, we advise you to reach out to our seller for accurate pricing information. Thank you for considering our company for your needs, and we look forward to hearing from you soon.
| Overview | |
catalog | abs131497 |
Description | TRAF1 is an important adaptor molecule that possesses the ability to modulate the activation of NF-kappa-B and JNK. This protein plays a crucial role in regulating cell survival as well as apoptosis. By forming a heterotrimer with TRAF2, TRAF1 takes part in a complex that has E3 ubiquitin-protein ligase activity, which promotes ubiquitination of numerous target proteins including MAP3K14. Furthermore, the TRAF1/TRAF2 complex is capable of attracting the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2, indicating its vital role in the regulation of cell death and survival mechanisms. |
| Other names | TRAF1, also known as Epstein-Barr virus-induced protein 6 or EBI6, is a TNF receptor-associated factor 1 that is encoded by the gene 4732496E14Rik. This protein plays a vital role in the immune system's response to inflammation and infection. Its association with the TNF receptor suggests that TRAF1 is involved in regulating the activation of NF-kB and JNK signaling pathways. The MGC:10353 is also linked to TRAF1, and it is potentially associated with cell proliferation and differentiation. As a promising target for autoimmune and inflammatory diseases, TRAF1 is currently being studied for its therapeutic potential. |
| Source | Rabbit |
| Specificity | The total TRAF1 protein can be detected using the TRAF1 Antibody at its endogenous levels. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine |
| Antigen | TRAF1 |
| Application | ： 1. WB1:5001:2000。 2. IHC1:501:200。 3. ELISA（）1:200001:40000。 。，。，，，。 |
| Immunogen | A synthesized peptide derived from human TRAF1. |
| MW | 46 kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | To obtain a purified antiserum, the SulfoLink™ Coupling Resin was employed in peptide affinity chromatography. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. |
| Posttranslational modification | Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation. |
| Celluar localization | Cytosol; |
| UniPort | Q13077 |
This product is for research use only, not for use in diagnostic prodecures or in human.
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