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Rabbit Anti-TPPP Polyclonal Antibody#abs137357

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Description

Catalog-specification	Delivery time	USD price
abs137357-100ug	1-2 Weeks	301.0
abs137357-50ug	1-2 Weeks	201.0

Overview
catalog	abs137357
Other names	p25 alpha, also known as TPPP (Tubulin polymerization promoting protein), is a brain-specific protein with a molecular weight of 25 kDa. This protein acts as an inhibitor of glycogen synthase kinase 3 (GSK3) and is involved in the promotion of tubulin polymerization. Its unique properties make it a key player in brain-specific functions. p25 alpha, also referred to as TPPP1, is encoded by the gene OTTHUMP00000161630. It plays a crucial role in the regulation of neuronal development and function. The protein p25 alpha has been extensively studied and its importance in various brain-related processes has been highlighted. The function of p25 alpha lies in its ability to modulate tubulin polymerization, which is essential for the proper formation and stabilization of microtubules in the brain. By inhibiting GSK3, p25 alpha promotes tubulin polymerization, leading to the assembly of microtubules and facilitating their functions in neuronal processes. This protein is specifically expressed in the brain, making it a critical component for neuronal activity. The significance of p25 alpha in neuronal processes is underscored by its association with various neurological disorders. Alterations in the expression or activity of p25 alpha have been linked to conditions such as Alzheimer's disease, Parkinson's disease, and certain types of neuropathies. These findings suggest that p25 alpha plays a crucial role in maintaining proper neuronal function and its dysregulation can have detrimental effects on brain health. In summary, p25 alpha, also known as TPPP, is a brain-specific protein with a molecular weight of 25 kDa. It acts as an inhibitor of GSK3 and promotes tubulin polymerization, facilitating the formation and stabilization of microtubules in the brain. Its unique properties and association with neurological disorders highlight its essential role in maintaining proper neuronal function.
Source	Rabbit
Specificity	The TPPP Antibody is designed to identify the presence of total TPPP within the body at its natural levels. By detecting endogenous levels, this antibody serves as a valuable tool for studying the overall expression of TPPP protein. Utilizing this antibody allows researchers to gain insights into the roles and functions of TPPP in various biological processes. Remember, it is crucial to conduct further experiments and controls to validate the results obtained from using the TPPP Antibody.
Species Reactivity	Human
Antigen	TPPP
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human TPPP.
MW	24kDa
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was used in the purification process of the antiserum through peptide affinity chromatography. The resulting outcome was a highly purified antiserum, free from any contaminants or impurities. This method is highly effective in separating the target molecules from the complex mixture, ensuring a high yield and purity of the final product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure proper storage, it is recommended to keep the product at a temperature of -20°C for one year. To avoid any potential damage, it is highly advised to avoid exposing the product to repeated freeze/thaw cycles.
Storage buffer	The provided information is about Rabbit IgG, which is stored in a solution containing phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this solution at a temperature of -20 °C. The Rabbit IgG is considered stable for a period of 12 months from the date of receipt.
Target
Background	May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
Tissue specificity	Widely expressed.
Posttranslational modification	Poor substrate for GSK3 (By similarity). Phosphorylated by LIMK1 on serine residues. Phosphorylation may alter the tubulin polymerization activity.
Celluar localization	Cytoskeleton;Cytosol;Mitochondrion;Nucleus;
UniPort	O94811