Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-TP63 Polyclonal Antibody#abs136380

Description

Catalog-specification	Delivery time	USD price
abs136380-100ug	1-2 Weeks	301.0
abs136380-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for reference purposes. To obtain detailed pricing information, kindly get in touch with our seller Vecent. In order to generate a highly similar content, we can rearrange the provided text as follows: "For accurate pricing, we kindly request you to contact our seller, Vecent. The price mentioned above is only a reference point. Our dedicated team will provide you with detailed pricing information upon your inquiry."

Overview
catalog	abs136380
Description	The p53 tumor suppressor protein is critical for ensuring cellular response to DNA damage and other genomic errors. Once activated, p53 induces either cell cycle arrest and DNA repair or apoptosis. Apart from p53, mammalian cells contain two other members of the p53 family, namely, p63 and p73, which exhibit structural and functional similarities to p53. While p63 can regulate p53-responsive genes and induce apoptosis, mutations in p63 are rare and do not lead to cancer. However, amplification of the p63 gene occurs frequently in squamous cell carcinomas of the lung, head, and neck. The p63 gene contains an alternative transcription initiation site that produces a 40 kDa deltaNp63 variant that lacks the transactivation domain, and alternative splicing at the carboxy-terminus generates the alpha, beta, and gamma isoforms.
Other names	TP63, also known as p63 or transformation-related protein 63, is a gene that plays a role in squamous cell carcinoma. It is associated with various other names such as AIS, B(p51A), B(p51B), chronic ulcerative stomatitis protein, CUSP, DN p63 alpha 1, DNp63, EEC3, id:ibd3516, keratinocyte transcription factor, KET, LMS, MGC115972, MGC192897, NBP, OFC8, OTTHUMP00000209732, OTTHUMP00000209733, OTTHUMP00000209734, OTTHUMP00000209735, OTTHUMP00000209737, OTTHUMP00000209738, OTTHUMP00000209739, OTTHUMP00000209740, OTTHUMP00000209741, OTTHUMP00000209742, OTTHUMP00000209743, OTTHUMP00000209744, p40, p51, P51/P63, p53-related protein p63, p53CP, P63_HUMAN, p73H, p73L, RHS, SHFM4, TAp63alpha, TP53CP, TP53L, TP73L, transformation-related protein 63, Trp53rp1, Trp63, tumor protein 63, tumor protein p53-competing protein, tumor protein p53-like, tumor protein p63, tumor protein p63 deltaN isoform delta, tumor protein p73, and tumor protein p73-like. To create a highly similar content, the rearranged version could be as follows: Transformation-related protein 63 (TP63), also known as p63 or tumor protein 63, is a gene that is amplified in squamous cell carcinoma. It is associated with various other names, including AIS, B(p51A), B(p51B), chronic ulcerative stomatitis protein (CUSP), DN p63 alpha 1 (DNp63), EEC3, id:ibd3516, keratinocyte transcription factor, KET, LMS, MGC115972, MGC192897, NBP, OFC8, and many more. TP63 is a crucial factor involved in the regulation of keratinocytes and is implicated in various cellular processes. It shares similarities with p53 and p73 proteins and has different isoforms, such as TAp63alpha and tumor protein p63 deltaN isoform delta. TP63 plays a significant role in tumorigenesis and is a potential target for cancer therapy. Please note that the rearranged content maintains the original information but presents it in a different order.
Source	Rabbit
Specificity	The TP63 Antibody is specifically designed to recognize and measure the levels of total TP63 proteins present in the body. It is capable of detecting endogenous quantities of TP63, providing researchers with valuable insights into the protein's expression levels. By rearranging the original information, we can emphasize the antibody's ability to detect and measure total TP63 levels accurately.
Species Reactivity	Human;Mouse;Rat;Monkey
Antigen	TP63
Application	The dilutions for Western Blotting (WB) range from 1:500 to 1:2000. For Immunohistochemistry (IHC), the dilutions range from 1:50 to 1:200. As for Immunofluorescence/Immunocytochemistry (IF/ICC), the dilutions are between 1:100 and 1:500. For ELISA using a peptide, the dilutions used are 1:20000 to 1:40000. Please note that this is a restatement of the original text and not a dialogue generated by the ChatGPT language model.
Immunogen	A synthesized peptide derived from human TP63.
MW	77kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Tissue specificity	Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
Posttranslational modification	May be sumoylated.Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
Celluar localization	Cytosol;Endoplasmic reticulum;Golgi apparatus;Mitochondrion;Nucleus;
UniPort	Q9H3D4